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Literature summary for 3.4.21.109 extracted from

  • Lin, C.Y.; Tseng, I.C.; Chou, F.P.; Su, S.F.; Chen, Y.W.; Johnson, M.D.; Dickson, R.B.
    Zymogen activation, inhibition, and ectodomain shedding of matriptase (2008), Front. Biosci., 13, 621-635.
    View publication on PubMed
Search for more literature for 3.4.21.109

Activating Compound

Activating Compound Comment Organism Structure
additional information zymogen activation is stimulated by suramin, lysophosphatidic acid, and sphingosine 1-phosphate, overview Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
hepatocyte growth factor activator inhibitor-1 HAI-1, a Kunitz-type transmembrane serine protease inhibitor, cognate inhibitor of matriptase with regulatory function, molecular mechanism of inhibition, domain structure of HAI-1, proteolytic processing during maturation, activation, and shedding, enzyme-inhibitor complex structure, overview, the level of HAI-1 expression seems to be an important factor in the regulation of matriptase zymogen activation Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cell surface
-
 Homo sapiens 9986
-
membrane matriptase is a type II transmembrane protein Homo sapiens 16020
-
additional information molecular mechanism of ectodomain shedding, overview Homo sapiens
-
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
95000
-
 x * 95000, single-chain latent enzyme, SDS-PAGE, x * 120000, active enzyme in complex with inhibitor HAI-1, SDS-PAGE Homo sapiens
120000
-
 x * 95000, single-chain latent enzyme, SDS-PAGE, x * 120000, active enzyme in complex with inhibitor HAI-1, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
hepatocyte growth factor/scatter factor + H2O Homo sapiens activation activated hepatocyte growth factor/scatter factor + ?
-
 ?
IGFBP-rP1 + H2O Homo sapiens
-
 ?
-
 ?
insulin-like growth factor binding protein-related protein-1 + H2O Homo sapiens activation ?
-
 ?
matrix metalloprotease-3 + H2O Homo sapiens activation ?
-
 ?
additional information Homo sapiens physiological regulatory mechanisms, overview, matriptase is involved in cancer invasion and metastasis by serving as a membrane activator directly on cancer cell surfaces to recruit and activate urokinase type plasminogen activator, MMP-3, hepatocyte growth factor, and insulin-like growth factor binding protein-related protein-1, all of which are important in various aspects of cancers, including extracellular matrix degradation, adhesion, cellular motility and tumor vascularization ?
-
 ?
pro-urokinase plasminogen activator + H2O Homo sapiens activation urokinase plasminogen activator + propeptide of urokinase plasminogen activator
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein putative N-linked glycosylation sites, overview Homo sapiens
proteolytic modification proteolytic processing during maturation, activation, and shedding, molecular mechanism of zymogen activation and autoactivation, cleavage at Gly149 within the SEA domain, overview, the level of HAI-1 expression seems to be an important factor in the regulation of matriptase zymogen activation, matriptase zymogen activation may be regulated by two independent mechanisms: a soluble, cytosolic suppressor and autonomous, lipid anchored activation machinery at the lipid bilayer biomembrane Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
184A1N4 cell
-
 Homo sapiens
-
breast cancer cell
-
 Homo sapiens
-
epithelium co-expression and co-localization of both matriptase and HAI-1 in many epithelial cells, complex formation, overview Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
hepatocyte growth factor/scatter factor + H2O
-
 Homo sapiens activated hepatocyte growth factor/scatter factor + ?
-
 ?
hepatocyte growth factor/scatter factor + H2O activation Homo sapiens activated hepatocyte growth factor/scatter factor + ?
-
 ?
IGFBP-rP1 + H2O
-
 Homo sapiens ?
-
 ?
insulin-like growth factor binding protein-related protein-1 + H2O activation Homo sapiens ?
-
 ?
insulin-like growth factor binding protein-related protein-1 + H2O i.e. IGFBP-rP1 Homo sapiens ?
-
 ?
matrix metalloprotease-3 + H2O
-
 Homo sapiens ?
-
 ?
matrix metalloprotease-3 + H2O activation Homo sapiens ?
-
 ?
additional information physiological regulatory mechanisms, overview, matriptase is involved in cancer invasion and metastasis by serving as a membrane activator directly on cancer cell surfaces to recruit and activate urokinase type plasminogen activator, MMP-3, hepatocyte growth factor, and insulin-like growth factor binding protein-related protein-1, all of which are important in various aspects of cancers, including extracellular matrix degradation, adhesion, cellular motility and tumor vascularization Homo sapiens ?
-
 ?
pro-urokinase plasminogen activator + H2O
-
 Homo sapiens urokinase plasminogen activator + propeptide of urokinase plasminogen activator
-
 ?
pro-urokinase plasminogen activator + H2O activation Homo sapiens urokinase plasminogen activator + propeptide of urokinase plasminogen activator
-
 ?

Subunits

Subunits Comment Organism
? x * 95000, single-chain latent enzyme, SDS-PAGE, x * 120000, active enzyme in complex with inhibitor HAI-1, SDS-PAGE Homo sapiens
More domain structure of matriptase, overview Homo sapiens

Synonyms

Synonyms Comment Organism
membrane-type serine protease-1
-
 Homo sapiens
More matriptase is a member of the type II transmembrane serine protease family Homo sapiens
MT-SP1
-
 Homo sapiens
ST14
-
 Homo sapiens
suppressor of tumorigenicity-14
-
 Homo sapiens
TADG-15
-
 Homo sapiens
tumor-associated differentially expressed gene-15
-
 Homo sapiens