Literature summary for 3.4.21.109 extracted from

Ramsay, A.J.; Reid, J.C.; Velasco, G.; Quigley, J.P.; Hooper, J.D.
The type II transmembrane serine protease matriptase-2 - identification, structural features, enzymology, expression pattern and potential roles (2008), Front. Biosci., 13, 569-579.

Search for more literature for 3.4.21.109

Cloned(Commentary)

Cloned (Comment)	Organism
DNA and amino acid sequence comparison, genetic structure, phylogenetic analysis, regulation of enzyme expression, overview	Homo sapiens
DNA and amino acid sequence comparison, genetic structure, phylogenetic analysis, regulation of enzyme expression, overview	Rattus norvegicus
DNA and amino acid sequence comparison, genetic structure, phylogenetic analysis, regulation of enzyme expression, overview	Bos taurus
DNA and amino acid sequence comparison, genetic structure, phylogenetic analysis, regulation of enzyme expression, overview	Canis lupus familiaris
DNA and amino acid sequence comparison, genetic structure, phylogenetic analysis, regulation of enzyme expression, overview	Macaca mulatta
DNA and amino acid sequence comparison, genetic structure, phylogenetic analysis, regulation of enzyme expression, overview	Mus musculus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cell surface	-	Homo sapiens	9986	-
cell surface	-	Rattus norvegicus	9986	-
cell surface	-	Bos taurus	9986	-
cell surface	-	Canis lupus familiaris	9986	-
cell surface	-	Macaca mulatta	9986	-
cell surface	-	Mus musculus	9986	-
membrane	matriptase-2 is a type II transmembrane serine protease	Homo sapiens	16020	-
membrane	matriptase-2 is a type II transmembrane serine protease	Rattus norvegicus	16020	-
membrane	matriptase-2 is a type II transmembrane serine protease	Bos taurus	16020	-
membrane	matriptase-2 is a type II transmembrane serine protease	Canis lupus familiaris	16020	-
membrane	matriptase-2 is a type II transmembrane serine protease	Macaca mulatta	16020	-
membrane	matriptase-2 is a type II transmembrane serine protease	Mus musculus	16020	-

Organism

Organism	UniProt	Comment	Textmining
Bos taurus	-	-	-
Canis lupus familiaris	-	-	-
Homo sapiens	-	-	-
Macaca mulatta	-	-	-
Mus musculus	Q9DBI0	-	-
Rattus norvegicus	-	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
glycoprotein	the enzyme contains N-glycosylation sites, overview	Homo sapiens
glycoprotein	the enzyme contains N-glycosylation sites, overview	Rattus norvegicus
glycoprotein	the enzyme contains N-glycosylation sites, overview	Bos taurus
glycoprotein	the enzyme contains N-glycosylation sites, overview	Canis lupus familiaris
glycoprotein	the enzyme contains N-glycosylation sites, overview	Macaca mulatta
glycoprotein	the enzyme contains N-glycosylation sites, overview	Mus musculus

Reaction

Reaction	Comment	Organism	Reaction ID
cleaves various synthetic substrates with Arg or Lys at the P1 position and prefers small side-chain amino acids, such as Ala and Gly, at the P2 position	structure-function relationship, overview	Homo sapiens	a
cleaves various synthetic substrates with Arg or Lys at the P1 position and prefers small side-chain amino acids, such as Ala and Gly, at the P2 position	structure-function relationship, overview	Rattus norvegicus	a
cleaves various synthetic substrates with Arg or Lys at the P1 position and prefers small side-chain amino acids, such as Ala and Gly, at the P2 position	structure-function relationship, overview	Bos taurus	a
cleaves various synthetic substrates with Arg or Lys at the P1 position and prefers small side-chain amino acids, such as Ala and Gly, at the P2 position	structure-function relationship, overview	Canis lupus familiaris	a
cleaves various synthetic substrates with Arg or Lys at the P1 position and prefers small side-chain amino acids, such as Ala and Gly, at the P2 position	structure-function relationship, overview	Macaca mulatta	a
cleaves various synthetic substrates with Arg or Lys at the P1 position and prefers small side-chain amino acids, such as Ala and Gly, at the P2 position	structure-function relationship, overview	Mus musculus	a

Source Tissue

Source Tissue	Comment	Organism	Textmining
adult	-	Homo sapiens	-
adult	-	Rattus norvegicus	-
adult	-	Mus musculus	-
embryo	-	Homo sapiens	-
embryo	-	Rattus norvegicus	-
embryo	-	Mus musculus	-
additional information	tissue expression pattern, overview	Homo sapiens	-
additional information	tissue expression pattern, overview	Rattus norvegicus	-
additional information	tissue expression pattern, overview	Mus musculus	-

Subunits

Subunits	Comment	Organism
More	matriptase-2 contains a short cytoplasmic amino terminal tail, a transmembrane region, a stem region containing two CUB domains and three LDL receptor class A domains, and at the carboxy terminal a trypsin-like serine protease domain, domain structure, structure-function relationship, overview	Homo sapiens
More	matriptase-2 contains a short cytoplasmic amino terminal tail, a transmembrane region, a stem region containing two CUB domains and three LDL receptor class A domains, and at the carboxy terminal a trypsin-like serine protease domain, domain structure, structure-function relationship, overview	Rattus norvegicus
More	matriptase-2 contains a short cytoplasmic amino terminal tail, a transmembrane region, a stem region containing two CUB domains and three LDL receptor class A domains, and at the carboxy terminal a trypsin-like serine protease domain, domain structure, structure-function relationship, overview	Bos taurus
More	matriptase-2 contains a short cytoplasmic amino terminal tail, a transmembrane region, a stem region containing two CUB domains and three LDL receptor class A domains, and at the carboxy terminal a trypsin-like serine protease domain, domain structure, structure-function relationship, overview	Canis lupus familiaris
More	matriptase-2 contains a short cytoplasmic amino terminal tail, a transmembrane region, a stem region containing two CUB domains and three LDL receptor class A domains, and at the carboxy terminal a trypsin-like serine protease domain, domain structure, structure-function relationship, overview	Macaca mulatta
More	matriptase-2 contains a short cytoplasmic amino terminal tail, a transmembrane region, a stem region containing two CUB domains and three LDL receptor class A domains, and at the carboxy terminal a trypsin-like serine protease domain, domain structure, structure-function relationship, overview	Mus musculus

Synonyms

Synonyms	Comment	Organism
matriptase-2	-	Homo sapiens
matriptase-2	-	Rattus norvegicus
matriptase-2	-	Bos taurus
matriptase-2	-	Canis lupus familiaris
matriptase-2	-	Macaca mulatta
matriptase-2	-	Mus musculus
More	matriptase-2 is a member of the type II transmembrane serine protease, TTSP, family	Homo sapiens
More	matriptase-2 is a member of the type II transmembrane serine protease, TTSP, family	Rattus norvegicus
More	matriptase-2 is a member of the type II transmembrane serine protease, TTSP, family	Bos taurus
More	matriptase-2 is a member of the type II transmembrane serine protease, TTSP, family	Canis lupus familiaris
More	matriptase-2 is a member of the type II transmembrane serine protease, TTSP, family	Macaca mulatta
More	matriptase-2 is a member of the type II transmembrane serine protease, TTSP, family	Mus musculus
TMPRSS6	-	Homo sapiens
TMPRSS6	-	Rattus norvegicus
TMPRSS6	-	Bos taurus
TMPRSS6	-	Canis lupus familiaris
TMPRSS6	-	Macaca mulatta
TMPRSS6	-	Mus musculus

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Release 2023.1 (January 2023)