Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | the enzyme is induced by lysophospholipids, androgens, and the polyanionic suramin, the agents induce different signaling pathways and cellular events in a cell type-specific manner leading to matriptase activation, which requires an intact lipid bilayer microenvironment, enzyme activation within the range of pH 5.2-7.2, overview, inhibition of matriptase activation in vitro and in vivo, overview | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
anti-matriptase LDL receptor domain 3-specific monoclonal antibodies | complete inhibition of enzyme activation | Homo sapiens | |
hepatocyte growth factor activator inhibitor-1 | HAI-1 | Homo sapiens | |
additional information | inhibition of matriptase activation in vitro and in vivo, overview | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endoplasmic reticulum | - |
Homo sapiens | 5783 | - |
Golgi membrane | - |
Homo sapiens | 139 | - |
membrane | bound | Homo sapiens | 16020 | - |
perinuclear space | - |
Homo sapiens | - |
- |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
70000 | - |
x * 70000, inactive zymogen, SDS-PAGE | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
proteolytic modification | matriptase performs autoactivation | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
184A1N4 cell | mammary epithelial cell line | Homo sapiens | - |
LNCaP cell | - |
Homo sapiens | - |
MCF-7 cell | - |
Homo sapiens | - |
T-47D cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | matriptase performs autoactivation | Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 70000, inactive zymogen, SDS-PAGE | Homo sapiens |