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Literature summary for 3.4.21.109 extracted from

  • Benaud, C.; Oberst, M.; Hobson, J.P.; Spiegel, S.; Dickson, R.B.; Lin, C.Y.
    Sphingosine 1-phosphate, present in serum-derived lipoproteins, activates matriptase (2002), J. Biol. Chem., 277, 10539-10546.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
C2 ceramide 1-phosphate weaker activator than sphingosine 1-phosphate, activation at 0.000237 mM Homo sapiens
C8 ceramide 1-phosphate weaker activator than sphingosine 1-phosphate, activation at 0.001 mM Homo sapiens
dihydrosphingosine 1-phosphate weaker activator than sphingosine 1-phosphate Homo sapiens
lysophosphatidic acid weaker activator than sphingosine 1-phosphate Homo sapiens
sphingosine 1-phosphate activation at 0.00001 mg/ml, activation is dependent on Ca2+ Homo sapiens
sphingosine phosphocholine weaker activator than sphingosine 1-phosphate Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expression in MDA-MB-435 breast caner cells Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
70000
-
non-complexed form, SDS-PAGE Homo sapiens
120000
-
complexed form, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens degrades extracellular matrix ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
epithelium
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information degrades extracellular matrix Homo sapiens ?
-
?