Literature summary for 3.4.21.108 extracted from

Sosna, J.; Voigt, S.; Mathieu, S.; Kabelitz, D.; Trad, A.; Janssen, O.; Meyer-Schwesinger, C.; Schuetze, S.; Adam, D.
The proteases HtrA2/Omi and UCH-L1 regulate TNF-induced necroptosis (2013), Cell Commun. Signal., 11, 76.

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Organism

Organism	UniProt	Comment	Textmining
Mus musculus	Q9JIY5	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
NIH-3T3 cell	-	Mus musculus	-

Synonyms

Synonyms	Comment	Organism
HtrA2/Omi	-	Mus musculus

General Information

General Information	Comment	Organism
physiological function	pharmacological inhibition or genetic deletion of enzyme HtrA2/Omi protects from TNF-induced necroptosis. HtrA2/Omi does not cleave ubiquitin C-terminal hydrolase UCH-L1 during TNF-induced necroptosis, but rather induces monoubiquitination indicative for UCH-L1 activation. Correspondingly, pharmacologic or RNA interference-mediated inhibition of UCH-L1 protects from TNF-induced necroptosis	Mus musculus

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Release 2023.1 (January 2023)