Protein Variants | Comment | Organism |
---|---|---|
additional information | the activity to delay the aggreagtion is significantly enhanced when the PDZ domain is removed suggesting an inhibitory role for this domain on the activity | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Synonyms | Comment | Organism |
---|---|---|
HtrA2 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | HtrA2 has a moderate ability to delay the aggregation of citrate synthase in vitro. Additionally, using electron microscopy and nuclear magnetic resonance analyses, it is observed that HtrA2 significantly delays the aggregation of the Abeta1-42 peptide. The protease activity of HtrA2 and its PDZ domain are not essential for the delay of Abeta1-42 peptide aggregation | Homo sapiens |