Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.21.108 extracted from

  • Kieper, N.; Holmstroem, K.M.; Ciceri, D.; Fiesel, F.C.; Wolburg, H.; Ziviani, E.; Whitworth, A.J.; Martins, L.M.; Kahle, P.J.; Krueger, R.
    Modulation of mitochondrial function and morphology by interaction of Omi/HtrA2 with the mitochondrial fusion factor OPA1 (2010), Exp. Cell Res., 316, 1213-1224.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.108

Cloned(Commentary)

Cloned (Comment) Organism
expressed in human embryonic kindney cells and in Escherichia coli Homo sapiens

Protein Variants

Protein Variants Comment Organism
S306A mutant shows abolished protease activity Drosophila melanogaster
S306A mutant shows abolished protease activity Mus musculus
S306A mutant shows abolished protease activity Homo sapiens
S306A protease dead mutant Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Mus musculus 5829
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
35000
-
 endogenous Omi/HtrA2, SDS-PAGE Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens co-immunoprecipitation show direct interaction of Omi/HtrA2 with optic atrophy protein 1 (OPA1) ?
-
 ?

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster
-
-
-
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Mus musculus
-
MEF cell
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
beta-casein + H2O
-
 Mus musculus ?
-
 ?
additional information co-immunoprecipitation show direct interaction of Omi/HtrA2 with optic atrophy protein 1 (OPA1) Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
high temperature requirement protein A2
-
 Mus musculus
HtrA2
-
 Mus musculus
Omi
-
 Mus musculus
Omi/HtrA2
-
 Drosophila melanogaster
Omi/HtrA2
-
 Mus musculus
Omi/HtrA2
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction in Omi/HtrA2 knockout mouse embryonic fibroblasts elongated mitochondria are found by live cell imaging. Electron microscopy confirm the mitochondrial morphology alterations and show abnormal cristae structure. Examining the levels of proteins involved in mitochondrial fusion, a selective up-regulation of optic atrophy protein 1 is shown. Complementation of knockout cells with human wild-type Omi/HtrA2 reverses the mitochondrial elongation phenotype and optic atrophy protein 1 alterations Mus musculus
malfunction in Omi/HtrA2 silenced Drosophila S2R+ cells elongated mitochondria are found by live cell imaging. Electron microscopy confirm the mitochondrial morphology alterations and show abnormal cristae structure. Examining the levels of proteins involved in mitochondrial fusion, a selective up-regulation of optic atrophy protein 1 is shown Drosophila melanogaster
malfunction in Omi/HtrA2 silenced human HeLa elongated mitochondria are found by live cell imaging. Electron microscopy confirm the mitochondrial morphology alterations and show abnormal cristae structure. Examining the levels of proteins involved in mitochondrial fusion, a selective up-regulation of optic atrophy protein 1 is shown Homo sapiens
malfunction Omi/HtrA2 knockout mice show significant increase in intramitochondrial reactive oxygen species and decreased mitochondrial membrane potential in MEF cells Mus musculus
physiological function Omi/HtrA2 functionally and physically interacts with the mitochondrial fusion protein OPA1. Mitochondrial morphology relies on Omi/HtrA2 protease function Mus musculus