Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | phosphorylation | Homo sapiens |
Application | Comment | Organism |
---|---|---|
medicine | the identification of the role of HtrA2 in neurodegeneration will lead to an improved understanding of the pathogenesis of Parkinsons disease | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
A141S | polymorphism associated with Parkinsons disease | Homo sapiens |
G399S | heterozygous mutation identified in Parkinsons disease patients | Homo sapiens |
S142D | recombinant HtrA2 mutant, produced to determine whether HtrA2 phosphorylation affects its proteolytic activity | Homo sapiens |
S400D | recombinant HtrA2 mutant, produced to determine whether HtrA2 phosphorylation affects its proteolytic activity | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Homo sapiens | 5739 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
35000 | - |
determined by SDS-PAGE and Western Blot analysis | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | Ser142 and Ser400 | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
HtrA2 | - |
Homo sapiens |