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Literature summary for 3.4.21.108 extracted from

  • Ma, X.; Kalakonda, S.; Srinivasula, S.M.; Reddy, S.P.; Platanias, L.C.; Kalvakolanu, D.V.
    GRIM-19 associates with the serine protease HtrA2 for promoting cell death (2007), Oncogene, 26, 4842-4849.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
GRIM-19 direct enhancement of HtrA2 activity in vitro. HtrA2-driven destruction of the antiapoptotic X-linked inhibitor of apoptosis protein is augmented Homo sapiens
IFN/all-trans retinoic acid enhances interaction of GRIM-19 with HtrA2. Causes a concurrent release of HtrA2 and GRIM-19 from mitochondria Homo sapiens

Application

Application Comment Organism
medicine critical role of HtrA2 in a cytokine-induced cell death response. Inhibition by a viral protein Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
coexpression of Flag-tagged and Ndelta133 HtrA2 proteins and a myc-epitope-tagged GRIM-19 protein in MCF-7 cells. MCF-7 cells transfected with expression vectors coding for GFP-HtrA2 and GFP-HtrA2-S306A and GRIM-19 Homo sapiens

Protein Variants

Protein Variants Comment Organism
S306A catalytically inactive Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
antisense HtrA2 significantly inhibits IFN/all-trans retinoic acid-induced degradation of X-linked inhibitor of apoptosis protein Homo sapiens
vIRF1 human herpes virus-8 (HHV-8)-coded oncoprotein, disrupts interactions of GRIM-19 with HtrA2 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Homo sapiens 5739
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
MCF-7 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
X-linked inhibitor of apoptosis protein + H2O
-
Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
serine protease HtrA2
-
Homo sapiens