Application | Comment | Organism |
---|---|---|
medicine | HtrA2 knockout mice display features characteristic of a Parkinson syndrome, deletion of HtrA2 results in increased susceptibility to cell death stimuli, Smac/DIABOLO can compensate for the removal of HtrA2 in terms of neutralizing inhibitor of apoptosis proteins | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | HtrA2 knockout mice with general decrease in organ size and neurological abnormalities, deletion of HtrA2 results in a mitochondrial dysfunction, death of these mice ca. 30 days after birth | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Mus musculus | 5737 | - |
mitochondrion | HtrA2 in the intermembrane space of healthy cells, density of mitochondria decreased and showed abnormal forms in knockout mice | Mus musculus | 5739 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Mus musculus | - |
embryonic stem cell | - |
Mus musculus | - |
MEF cell | - |
Mus musculus | - |
neuron | primary neurons | Mus musculus | - |
thalamus | - |
Mus musculus | - |
thymocyte | - |
Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
HtrA2/Omi | - |
Mus musculus |
serine protease | - |
Mus musculus |