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Literature summary for 3.4.21.108 extracted from

  • Martins, L.M.; Morrison, A.; Klupsch, K.; Fedele, V.; Moisoi, N.; Teismann, P.; Abuin, A.; Grau, E.; Geppert, M.; Livi, G.P.; Creasy, C.L.; Martin, A.; Hargreaves, I.; Heales, S.J.; Okada, H.; Brandner, S.; Schulz, J.B.; Mak, T.; Downward, J.
    Neuroprotective role of the Reaper-related serine protease HtrA2/Omi revealed by targeted deletion in mice (2004), Mol. Cell. Biol., 24, 9848-9862.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine HtrA2 knockout mice display features characteristic of a Parkinson syndrome, deletion of HtrA2 results in increased susceptibility to cell death stimuli, Smac/DIABOLO can compensate for the removal of HtrA2 in terms of neutralizing inhibitor of apoptosis proteins Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information HtrA2 knockout mice with general decrease in organ size and neurological abnormalities, deletion of HtrA2 results in a mitochondrial dysfunction, death of these mice ca. 30 days after birth Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
Mus musculus 5737
-
mitochondrion HtrA2 in the intermembrane space of healthy cells, density of mitochondria decreased and showed abnormal forms in knockout mice Mus musculus 5739
-

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Mus musculus
-
embryonic stem cell
-
Mus musculus
-
MEF cell
-
Mus musculus
-
neuron primary neurons Mus musculus
-
thalamus
-
Mus musculus
-
thymocyte
-
Mus musculus
-

Synonyms

Synonyms Comment Organism
HtrA2/Omi
-
Mus musculus
serine protease
-
Mus musculus