Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.21.108 extracted from

  • Gupta, S.; Singh, R.; Datta, P.; Zhang, Z.; Orr, C.; Lu, Z.; Dubois, G.; Zervos, A.S.; Meisler, M.H.; Srinivasula, S.M.; Fernandes-Alnemri, T.; Alnemri, E.S.
    The C-terminal tail of presenelin regulates Omi/HtrA2 protease activity (2004), J. Biol. Chem., 279, 45844-45854.
    View publication on PubMed
Search for more literature for 3.4.21.108

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli and MEF cells from mnd2 mouse Homo sapiens

Protein Variants

Protein Variants Comment Organism
L286V Alzheimer mutant presenilin-1 Homo sapiens
M146V Alzheimer mutant presenilin-1 Homo sapiens
S276C deletion of the PDZ domain of Omi/HtrA2 Homo sapiens
S306A catalytically inactive Omi/HtrA2 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Homo sapiens 5737
-
mitochondrion
-
 Homo sapiens 5739
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293 cell
-
 Homo sapiens
-
HeLa cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
35S-beta-casein + H2O C-terminus of presenilin-1 interacts the PDZ domain of with Omi/HtrA2, increasing its activity Homo sapiens ?
-
 ?
c-inhibitor of apoptosis protein1 + H2O C-terminus of presenilin-1 interacts with the PDZ domain of Omi/HtrA2, increasing its activity Homo sapiens ?
-
 ?
c-inhibitor of apoptosis protein2 + H2O C-terminus of presenilin-1 interacts with the PDZ domain of Omi/HtrA2, increasing its activity Homo sapiens ?
-
 ?
X-linked inhibitor of apoptosis protein + H2O C-terminus of presenilin-1 interacts with the PDZ domain of Omi/HtrA2, increasing its activity Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
Omi/HtrA2
-
 Homo sapiens
serine protease
-
 Homo sapiens