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Literature summary for 3.4.21.108 extracted from
- Autocatalytic processing of HtrA2/Omi is essential for induction of caspase-dependent cell death through antagonizing XIAP (2004), J. Biol. Chem., 279, 37588-37596.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| staurosporine | apoptotic stimulus to release 36-kDa protein fragment of HtrA2 and cytochrome c from the mitochondria to the cytosol | Homo sapiens |  |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression as GST fusions in Escherichia coli BL21 | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| S306A | endoproteolytic activity abolished | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Homo sapiens | 5829 | - |
| mitochondrion | - |
Homo sapiens | 5739 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
| Sus scrofa | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| by glutathione-Sepharose 4B beads | Homo sapiens |
Storage Stability
| Storage Stability | Organism |
|---|---|
| -70°C, Tris-HCl buffer, 20% glycerol, several months | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| beta-casein + H2O | - |
Homo sapiens | ? | - |
? | |
| X-linked inhibitor of apoptosis protein + H2O | autocatalytically processing of HtrA2 to the 36-kDa protein fragment, which is required for the cytochrome c-dependent caspase activation, promoting apoptotic cell death | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| HtrA2/Omi | - |
Mus musculus |
| HtrA2/Omi | - |
Homo sapiens |
| HtrA2/Omi | - |
Rattus norvegicus |
| HtrA2/Omi | - |
Sus scrofa |
| HtrA2/Omi | - |
Bos taurus |
| serine protease | - |
Mus musculus |
| serine protease | - |
Homo sapiens |
| serine protease | - |
Rattus norvegicus |
| serine protease | - |
Sus scrofa |
| serine protease | - |
Bos taurus |
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