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Literature summary for 3.4.21.108 extracted from
- Specific protein interaction of human Pag with Omi/HtrA2 and the activation of the protease activity of Omi/HtrA2 (2006), Free Radic. Biol. Med., 40, 275-284.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| overexpression in Escherichia coli BL21 (DE3) and expressed in Saccharomyces cerevisiae EGY48/pLexA-hPag and their mutants | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | HtrA2 released from the mitochondrion to the cytoplasm during apoptosis in response to oxidative stress | Homo sapiens | 5737 | - |
| mitochondrion | - |
Homo sapiens | 5739 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| sequential S-100 and S-200 gel filtration chromatography | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| beta-casein | protease activity is activated by the binding of the PDZ domain of the mature form of Omi to the C-terminal region of the reduced form of Pag | Homo sapiens | ? | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Omi/HtrA2 | - |
Homo sapiens |
| serine protease | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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