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Literature summary for 3.4.21.108 extracted from

  • Cilenti, L.; Kyrizis, G.A.; Soundarapandian, M.M.; Stratico, V.; Yerkes, A.; Park, K.M.; Sheridan, A.M.; Alnemri, E.S.; Bonventre, J.V.; Zervos, A.S.
    Omi/HtrA2 protease mediates cisplatin-induced cell death in renal cells (2005), Am. J. Physiol. Renal Physiol., 288, F371-F379.
    View publication on PubMed
Search for more literature for 3.4.21.108

Activating Compound

Activating Compound Comment Organism Structure
cisplatin increase of Omi protein Mus musculus
cisplatin increase of Omi protein Homo sapiens

Application

Application Comment Organism
medicine way to limit renal injury by specifically inhibiting its proteolytic activity Mus musculus
medicine way to limit renal injury by specifically inhibiting its proteolytic activity Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
ucf-101 blocks protease activity of Omi, protects renal cells from cisplatin-induced cell death, together with 0.05 mM cisplatin, 0.07 mM ucf-101 can block X-linked inhibitor of apoptosis protein degradation Homo sapiens
ucf-101 blocks protease activity of Omi, protects renal cells from cisplatin-induced cell death, mice treated with cisplatin and ucf-101 were more resistant to nephrotoxicy than animals treated with ciplatin alone Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Mus musculus 5737
-
cytoplasm
-
 Homo sapiens 5737
-
mitochondrion
-
 Homo sapiens 5739
-
mitochondrion predominant presence of Omi Mus musculus 5739
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
 C57BL6
-
Mus musculus C57BL6
-
 C57BL6
-

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293 cell
-
 Homo sapiens
-
kidney from human embryos Homo sapiens
-
kidney from the cortices Mus musculus
-
additional information proximal cells, HK-2 cells Homo sapiens
-
proximal tubule
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
X-linked inhibitor of apoptosis protein + H2O
-
 Mus musculus ?
-
 ?
X-linked inhibitor of apoptosis protein + H2O
-
 Homo sapiens ?
-
 ?
X-linked inhibitor of apoptosis protein + H2O
-
 Mus musculus C57BL6 ?
-
 ?

Synonyms

Synonyms Comment Organism
Omi/HtrA2 protease
-
 Mus musculus
Omi/HtrA2 protease
-
 Homo sapiens
serine protease
-
 Mus musculus
serine protease
-
 Homo sapiens