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Literature summary for 3.4.21.107 extracted from

  • Sanz Munoz, S.; Li, H.; Ruberu, K.; Chu, Q.; Saghatelian, A.; Ooi, L.; Garner, B.
    The serine protease HtrA1 contributes to the formation of an extracellular 25-kDa apolipoprotein E fragment that stimulates neuritogenesis (2018), J. Biol. Chem., 293, 4071-4084 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.107

Organism

Organism UniProt Comment Textmining
Homo sapiens Q92743
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-

Source Tissue

Source Tissue Comment Organism Textmining
brain
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 Homo sapiens
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SK-N-SH cell
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 Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
apolipoprotein-E + H2O
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 Homo sapiens ?
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 ?

General Information

General Information Comment Organism
physiological function siRNA-mediated knockdown of HtrA1 and a specific HtrA1 inhibitor reduce apolipoprotein-E 25-kDa fragment formation by 41 and 86%, respectively. HtrA1 regulates reduce apolipoprotein-E 25-kDa fragment formation under physiological conditions Homo sapiens