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Literature summary for 3.4.21.107 extracted from

  • Coleman, J.L.; Crowley, J.T.; Toledo, A.M.; Benach, J.L.
    The HtrA protease of Borrelia burgdorferi degrades outer membrane protein BmpD and chemotaxis phosphatase CheX (2013), Mol. Microbiol., 88, 619-633.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.107

Application

Application Comment Organism
medicine late stage Lyme disease patients, as well as infected mice and rabbits develop a robust antibody response to HtrA, indicating that it is a B-cell antigen Borreliella burgdorferi

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Borreliella burgdorferi

Protein Variants

Protein Variants Comment Organism
S198A loss of proteolytic activity Borreliella burgdorferi

Localization

Localization Comment Organism GeneOntology No. Textmining
periplasm enzyme occurs both membrane-bound and soluble Borreliella burgdorferi
-
-

Organism

Organism UniProt Comment Textmining
Borreliella burgdorferi O51131
-
-
Borreliella burgdorferi ATCC 35210 O51131
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
basic membrane protein D + H2O
-
 Borreliella burgdorferi ?
-
 ?
basic membrane protein D + H2O
-
 Borreliella burgdorferi ATCC 35210 ?
-
 ?
casein-FITC + H2O
-
 Borreliella burgdorferi ?
-
 ?
casein-FITC + H2O
-
 Borreliella burgdorferi ATCC 35210 ?
-
 ?
chemotaxis signal transduction phosphatase CheX + H2O
-
 Borreliella burgdorferi ?
-
 ?
chemotaxis signal transduction phosphatase CheX + H2O
-
 Borreliella burgdorferi ATCC 35210 ?
-
 ?

Synonyms

Synonyms Comment Organism
BB_0104
-
 Borreliella burgdorferi

General Information

General Information Comment Organism
physiological function enzyme is not able to complement an Escherichia coli DegP deletion mutant Borreliella burgdorferi