Protein Variants | Comment | Organism |
---|---|---|
S225A | inactive mutant | Campylobacter jejuni |
S236A | inactive mutant | Shigella flexneri |
S236A | inactive mutant | Escherichia coli |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | membrane-associated | Shigella flexneri | 16020 | - |
membrane | membrane-associated | Campylobacter jejuni | 16020 | - |
membrane | membrane-associated | Escherichia coli | 16020 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Campylobacter jejuni | - |
- |
- |
Escherichia coli | B7UIK8 | - |
- |
Escherichia coli E2348/69 | B7UIK8 | - |
- |
Shigella flexneri | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
casein + H2O | - |
Campylobacter jejuni | ? | - |
? | |
E-cadherin + H2O | enzyme cleaves E-cadherin on host cells | Shigella flexneri | ? | - |
? | |
E-cadherin + H2O | enzyme cleaves E-cadherin on host cells | Campylobacter jejuni | ? | - |
? | |
E-cadherin + H2O | enzyme cleaves E-cadherin on host cells | Escherichia coli | ? | - |
? | |
E-cadherin + H2O | enzyme cleaves E-cadherin on host cells | Escherichia coli E2348/69 | ? | - |
? |
General Information | Comment | Organism |
---|---|---|
physiological function | HtrA deletion leads to severe defects in E-cadherin cleavage, loss of cell adherence, paracellular transmigration, and basolateral invasion. A conserved pocket in the active center exhibits pronounced proteolytic activity | Campylobacter jejuni |