Organism | UniProt | Comment | Textmining |
---|---|---|---|
Streptococcus pneumoniae | - |
- |
- |
Synonyms | Comment | Organism |
---|---|---|
HtrA | - |
Streptococcus pneumoniae |
General Information | Comment | Organism |
---|---|---|
physiological function | HtrA mutants stimulate the blp locus which is responsible for the regulation and secretion of pneumococcal bacteriocins at lower cell density and to a greater extent than strains expressing wild-type HtrA. This effect is not due to direct proteolytic degradation of secreted pheromone by the protease, but instead is a result of HtrA-mediated disruption of peptide processing and secretion. HtrA restricts pneumocin production to high cell density by limiting the rate of accumulation of BlpC, a p eptide pheromone involved in quorum sensing, in the environment. HtrA does not interfere with the ability of a strain to sense environmental pheromones | Streptococcus pneumoniae |