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Literature summary for 3.4.21.107 extracted from

  • Kochan, T.J.; Dawid, S.
    The HtrA protease of Streptococcus pneumoniae controls density-dependent stimulation of the bacteriocin blp locus via disruption of pheromone secretion (2013), J. Bacteriol., 195, 1561-1572.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Streptococcus pneumoniae
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Synonyms

Synonyms Comment Organism
HtrA
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Streptococcus pneumoniae

General Information

General Information Comment Organism
physiological function HtrA mutants stimulate the blp locus which is responsible for the regulation and secretion of pneumococcal bacteriocins at lower cell density and to a greater extent than strains expressing wild-type HtrA. This effect is not due to direct proteolytic degradation of secreted pheromone by the protease, but instead is a result of HtrA-mediated disruption of peptide processing and secretion. HtrA restricts pneumocin production to high cell density by limiting the rate of accumulation of BlpC, a p eptide pheromone involved in quorum sensing, in the environment. HtrA does not interfere with the ability of a strain to sense environmental pheromones Streptococcus pneumoniae