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Literature summary for 3.4.21.107 extracted from

  • Clausen, T.; Kaiser, M.; Huber, R.; Ehrmann, M.
    HTRA proteases: regulated proteolysis in protein quality control (2011), Nat. Rev. Mol. Cell Biol., 12, 152-162.
    View publication on PubMed
Search for more literature for 3.4.21.107

Localization

Localization Comment Organism GeneOntology No. Textmining
cell envelope
-
 Escherichia coli 30313
-
chloroplast
-
 Arabidopsis thaliana 9507
-
chloroplast stroma isoform DEG2 only Arabidopsis thaliana 9570
-
cytoplasmic membrane isoform HTRA1 Homo sapiens
-
-
mitochondrion isoform HTRA2 Homo sapiens 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
biglycan + H2O Homo sapiens substrate of isoforms HTRA1 and HTRA3 ?
-
 ?
bone morphogenetic protein + H2O Homo sapiens substrate of isoform HTRA1 ?
-
 ?
decorin + H2O Homo sapiens substrate of isoforms HTRA1 and HTRA3 ?
-
 ?
E-cadherin + H2O Helicobacter pylori
-
 ?
-
 ?
Fibronectin + H2O Homo sapiens substrate of isoform HTRA1 ?
-
 ?
HCLS1-associated X1 + H2O Homo sapiens substrate of isoform HTRA2 ?
-
 ?
insulin growth factor-binding protein 5 + H2O Homo sapiens substrate of isoform HTRA1 ?
-
 ?
additional information Homo sapiens HTRA1 interacts with presenilin 1 to cleave one product of gamma-secretase ?
-
 ?
reaction centre protein D1 + H2O Escherichia coli substrate of isoform DEG1 ?
-
 ?
reaction centre protein D1 + H2O Arabidopsis thaliana substrate of isoform DEG1 ?
-
 ?
reaction centre protein D2 + H2O Escherichia coli substrate of isoforms DEG1, DEG5, DEG7 and DEG8 ?
-
 ?
reaction centre protein D2 + H2O Arabidopsis thaliana substrate of isoforms DEG1, DEG5, DEG7 and DEG8 ?
-
 ?
transforming growth factor-beta + H2O Homo sapiens substrate of isoform HTRA1 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana
-
-
-
Escherichia coli
-
-
-
Helicobacter pylori
-
-
-
Homo sapiens
-
-
-
Streptococcus mutans
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
biglycan + H2O substrate of isoforms HTRA1 and HTRA3 Homo sapiens ?
-
 ?
bone morphogenetic protein + H2O substrate of isoform HTRA1 Homo sapiens ?
-
 ?
decorin + H2O substrate of isoforms HTRA1 and HTRA3 Homo sapiens ?
-
 ?
E-cadherin + H2O
-
 Helicobacter pylori ?
-
 ?
Fibronectin + H2O substrate of isoform HTRA1 Homo sapiens ?
-
 ?
HCLS1-associated X1 + H2O substrate of isoform HTRA2 Homo sapiens ?
-
 ?
insulin growth factor-binding protein 5 + H2O substrate of isoform HTRA1 Homo sapiens ?
-
 ?
additional information HTRA1 interacts with presenilin 1 to cleave one product of gamma-secretase Homo sapiens ?
-
 ?
reaction centre protein D1 + H2O substrate of isoform DEG1 Escherichia coli ?
-
 ?
reaction centre protein D1 + H2O substrate of isoform DEG1 Arabidopsis thaliana ?
-
 ?
reaction centre protein D2 + H2O substrate of isoforms DEG1, DEG5, DEG7 and DEG8 Escherichia coli ?
-
 ?
reaction centre protein D2 + H2O substrate of isoforms DEG1, DEG5, DEG7 and DEG8 Arabidopsis thaliana ?
-
 ?
transforming growth factor-beta + H2O substrate of isoform HTRA1 Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
oligomer DegP protease chaperone system is regulated by oligomer conversion from the resting hexamer into the catalytically active 12mer and 24mer that capture and digest misfolded proteins Escherichia coli
trimer
-
 Homo sapiens
trimer
-
 Arabidopsis thaliana

Synonyms

Synonyms Comment Organism
Deg1 isoform Arabidopsis thaliana
DEG2 isoform Arabidopsis thaliana
DEG5 isoform Arabidopsis thaliana
DEG7 isoform Arabidopsis thaliana
DEG8 isoform Arabidopsis thaliana
DegP
-
 Escherichia coli
high temperature requirement A protease
-
 Escherichia coli
high temperature requirement A protease
-
 Homo sapiens
high temperature requirement A protease
-
 Arabidopsis thaliana
high temperature requirement A protease
-
 Helicobacter pylori
high temperature requirement A protease
-
 Streptococcus mutans
HtrA
-
 Escherichia coli
HtrA
-
 Arabidopsis thaliana
HtrA
-
 Streptococcus mutans
HtrA1 isoform Homo sapiens
HtrA1 isoform Helicobacter pylori
HtrA2 isoform Homo sapiens
HtrA3 isoform Homo sapiens
HTRA4 isoform Homo sapiens

Expression

Organism Comment Expression
Homo sapiens the activity of isoform HTRA2 is stimulated by phosphorylation downstream of PTEN-induced putative kinase 1 and the p38 stress kinase pathway up

General Information

General Information Comment Organism
malfunction the loss of HTRA activity is correlated with severe diseases, including arthritis, cancer, familial ischemic cerebral smallvessel disease and age-related macular degeneration, as well as Parkinson’s disease and Alzheimer’s disease Homo sapiens
physiological function HtrA acts as chaperone and protease Helicobacter pylori
physiological function HtrA acts as chaperone and protease. DEG1 interacts with the reaction centre protein D2 and assists in the assembly of photosystem II Escherichia coli
physiological function HtrA acts as chaperone and protease. DEG1 interacts with the reaction centre protein D2 and assists in the assembly of photosystem II Arabidopsis thaliana
physiological function HtrA is important for the biogenesis of extracellular proteins and thus for biofilm formation Streptococcus mutans
physiological function isoform HTRA1 regulates cell proliferation by sequestering or proteolysing transforming growth factor-beta and bone morphogenetic protein, proteins of the transforming growth factor family, and IGF-binding protein 5 in the extracellular matrix. Isoform HTRA2 affects quality control in the intermembrane space of mitochondria. HTRA1 and HTRA2 are implicated in tumor suppression and in the control of proliferation, migration and neurodegeneration. Isoform HTRA3 is implicated in pregnancy, and endometrial and ovarian cancers55 Homo sapiens