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Literature summary for 3.4.21.107 extracted from

  • Hoy, B.; Loewer, M.; Weydig, C.; Carra, G.; Tegtmeyer, N.; Geppert, T.; Schroeder, P.; Sewald, N.; Backert, S.; Schneider, G.; Wessler, S.
    Helicobacter pylori HtrA is a new secreted virulence factor that cleaves E-cadherin to disrupt intercellular adhesion (2010), EMBO Rep., 11, 798-804.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.107

Inhibitors

Inhibitors Comment Organism Structure
HpHtrA inhibitor small-molecule inhibitor that completely blocks E-cadherin cleavage by HtrA at 0.03 mM Helicobacter pylori

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
50000
-
 x * 50000, SDS-PAGE Helicobacter pylori

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
E-cadherin + H2O Helicobacter pylori selective substrate 85 kDa N-terminal fragment + 40 kDa C-terminal fragment
-
 ?
Fibronectin + H2O Helicobacter pylori selective substrate ?
-
 ?

Organism

Organism UniProt Comment Textmining
Helicobacter pylori
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Helicobacter pylori

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
casein + H2O
-
 Helicobacter pylori ?
-
 ?
E-cadherin + H2O selective substrate Helicobacter pylori 85 kDa N-terminal fragment + 40 kDa C-terminal fragment
-
 ?
Fibronectin + H2O selective substrate Helicobacter pylori ?
-
 ?
additional information the enzyme does not cleave recombinant immunoglobulin A, epidermal growth factor receptor or junctional adhesion molecule Helicobacter pylori ?
-
 ?

Subunits

Subunits Comment Organism
? x * 50000, SDS-PAGE Helicobacter pylori

Synonyms

Synonyms Comment Organism
high-temperature requirement A protease
-
 Helicobacter pylori
HtrA
-
 Helicobacter pylori

General Information

General Information Comment Organism
physiological function HtrA is a secreted virulence factor from Helicobacter pylori, which cleaves the ectodomain of E-cadherin. the E-cadherin shedding disrupts epithelial barrier functions allowing Helicobacter pylori to access the intercellular space Helicobacter pylori