Literature summary for 3.4.21.107 extracted from

Mo, E.; Peters, S.E.; Willers, C.; Maskell, D.J.; Charles, I.G.
Single, double and triple mutants of Salmonella enterica serovar typhimurium degP (htrA), degQ (hhoA) and degS (hhoB) have diverse phenotypes on exposure to elevated temperature and their growth in vivo is attenuated to different extents (2006), Microb. Pathog., 41, 174-182.

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Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	DegP and DegQ are constitutive, while DegS needs to be activated by an extracellular signal	Salmonella enterica subsp. enterica serovar Typhimurium

Cloned(Commentary)

Cloned (Comment)	Organism
gene degP, and two paralogues degQ and degS	Salmonella enterica subsp. enterica serovar Typhimurium

Protein Variants

Protein Variants	Comment	Organism
additional information	construction of deg deletion mutants by allelic replacement, the viability of degP and degS deletion mutants, as well as of the double mutant DELTAdegP-degS, is affected at elevated temperatures, while the degQ deletion mutant viability is not, also the triple mutant degP-degS-degQ is not severely affected, transfection of the mutants in the mouse-virulent strain SL1344 and injection into BALB/c mice, which leads attenuation of degP, degS, double, and triple mutants, while the degQ mutant is virulent as the wild-type strain, several maturally occuring mutations in the deg genes influence the virulence and pathology of Salmonella typhimurium strains, overview	Salmonella enterica subsp. enterica serovar Typhimurium

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Salmonella enterica subsp. enterica serovar Typhimurium	the enzyme is involved in survival of the bacteria under heat shock stress conditions in vitro and in vivo, overview	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Salmonella enterica subsp. enterica serovar Typhimurium	P26982	DegP; strain SL3261, gene degP or htrA	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	the enzyme is involved in survival of the bacteria under heat shock stress conditions in vitro and in vivo, overview	Salmonella enterica subsp. enterica serovar Typhimurium	?	-	?

Subunits

Subunits	Comment	Organism
hexamer	DegP, dimer of two trimers	Salmonella enterica subsp. enterica serovar Typhimurium
More	the Deg protein contain a catalytic domain with the serine protease catalytic triad, and C-terminal PDZ domains, two in DegP and DegQ, one in DegS	Salmonella enterica subsp. enterica serovar Typhimurium

Synonyms

Synonyms	Comment	Organism
DegP	-	Salmonella enterica subsp. enterica serovar Typhimurium
HtrA	-	Salmonella enterica subsp. enterica serovar Typhimurium

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Release 2023.1 (January 2023)