Activating Compound | Comment | Organism | Structure |
---|---|---|---|
puromycin | increases level of misfolded proteins, HtrA is required for growth under conditions in which misfolded proteins accumulate | Campylobacter jejuni |
Application | Comment | Organism |
---|---|---|
medicine | HtrA is important both for adherence to and invasion of human INT407 epithelial cells | Campylobacter jejuni |
Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli DH5alpha, BL20 and BL78 | Campylobacter jejuni |
Protein Variants | Comment | Organism |
---|---|---|
additional information | Escherichia coli HtrA mutant | Escherichia coli |
additional information | mutant strain NCTC11168deltahtrA cat, main part of the HtrA gene replaced | Campylobacter jejuni |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | wild type and HtrA mutant are not sensitive to H2O2, cumene hydroperoxide and paraquat, moreover the wild type is not sensitive to oxygen while the mutant has a reduced oxygen tolerance | Campylobacter jejuni |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
periplasm | - |
Campylobacter jejuni | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Campylobacter jejuni | - |
strain NCTC11168 | - |
Campylobacter jejuni NCTC 11168 | - |
strain NCTC11168 | - |
Escherichia coli | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|
Synonyms | Comment | Organism |
---|---|---|
HtrA protease | - |
Escherichia coli |
HtrA protease | - |
Campylobacter jejuni |
Temperature Minimum [°C] | Temperature Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | 44 | the HtrA mutant forms colonies with the same frequency as the wild type at 37°C and 42°C, the ability of the mutant to form colonies at 44°C was greatly reduced as compared to the wild type | Campylobacter jejuni |