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Literature summary for 3.4.21.107 extracted from

  • Clausen, T.; Southan, C.; Ehrmann, M.
    The HtrA family of proteases: implications for protein composition and cell fate (2002), Mol. Cell, 10, 443-455.
    View publication on PubMed
Search for more literature for 3.4.21.107

Activating Compound

Activating Compound Comment Organism Structure
additional information largely indpependent of activating compounds such as reducing agents Escherichia coli

Inhibitors

Inhibitors Comment Organism Structure
diisopropylfluorophosphate
-
 Escherichia coli

Localization

Localization Comment Organism GeneOntology No. Textmining
chloroplast
-
 Arabidopsis thaliana 9507
-
periplasm
-
 Escherichia coli
-
-
periplasm
-
 Rickettsia sp.
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
additional information largely independent of divalent cations Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Arabidopsis thaliana involved in the degradation of damaged proteins ?
-
 ?
additional information Homo sapiens involved in the degradation of damaged proteins, involved in arthritis, cell growth, stress response, apoptosis and aging, possible tumor suppressor function ?
-
 ?
additional information Escherichia coli involved in the degradation of damaged proteins, switches from chaperone to protease function in a temperature-dependent manner ?
-
 ?
Protein + H2O Escherichia coli
-
 ?
-
 ?
Protein + H2O Homo sapiens
-
 ?
-
 ?
Protein + H2O Arabidopsis thaliana
-
 ?
-
 ?
Protein + H2O Rickettsia sp.
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana
-
-
-
Escherichia coli
-
-
-
Homo sapiens
-
-
-
Rickettsia sp.
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
colon alternative splice form lacing exons 3 and 7 Homo sapiens
-
fibroblast
-
 Homo sapiens
-
kidney alternative splice form lacing exons 3 and 7 Homo sapiens
-
thyroid gland alternative splice form lacing exons 3 and 7 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
amylase MalS + H2O
-
 Rickettsia sp. ?
-
 ?
beta-casein + H2O cleaves beta-casein yielding several polypeptide fragments Escherichia coli ?
-
 ?
D1 protein + H2O degrades photodamaged D1 protein of photosystem II Arabidopsis thaliana ?
-
 ?
additional information acts on substrates that are at least partially unfolded, does not cleave stably folded proteins, acts as a general chaperone forming stable complexes with several misfolded proteins Escherichia coli ?
-
 ?
additional information involved in the degradation of damaged proteins Arabidopsis thaliana ?
-
 ?
additional information involved in the degradation of damaged proteins, involved in arthritis, cell growth, stress response, apoptosis and aging, possible tumor suppressor function Homo sapiens ?
-
 ?
additional information involved in the degradation of damaged proteins, switches from chaperone to protease function in a temperature-dependent manner Escherichia coli ?
-
 ?
Protein + H2O
-
 Escherichia coli ?
-
 ?
Protein + H2O
-
 Homo sapiens ?
-
 ?
Protein + H2O
-
 Arabidopsis thaliana ?
-
 ?
Protein + H2O
-
 Rickettsia sp. ?
-
 ?
Protein + H2O cleaves preferably at hydrophobic side chains at the P1 position Escherichia coli ?
-
 ?

Subunits

Subunits Comment Organism
hexamer two trimeric rings for a functional DegP hexamer Escherichia coli

Synonyms

Synonyms Comment Organism
DegP
-
 Arabidopsis thaliana
DegP
-
 Rickettsia sp.
HtrA
-
 Homo sapiens
HtrA classification of proteases Escherichia coli

Temperature Range [°C]

Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
20 30 almost no activity below 20°C, activity rapidly increases above 30°C Escherichia coli

Cofactor

Cofactor Comment Organism Structure
additional information largely indpependent of cofactors such as ATP Escherichia coli