Crystallization (Comment) | Organism |
---|---|
molecular docking of inhibitor. The P1 and P2 binding sites are occupied by the conserved Arg and then the variable second side chain, respectively. The 9-fluorenylmethyloxycarbonyl group forms pi-pi interactions with the conserved Trp in the P4 pocket | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
9-fluorenylmethyloxycarbonyl-NR-ketobenzothiazole | potent and selective inhibitor for hepsin over matriptase | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P05981 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Boc-QAR-7-amido-4-methylcoumarin + H2O | - |
Homo sapiens | Boc-QAR + 7-amino-4-methylcoumarin | - |
? |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0000017 | - |
9-fluorenylmethyloxycarbonyl-NR-ketobenzothiazole | pH not specified in the publication, temperature not specified in the publication | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | hepsin alone and not matriptase or HGFA plays a key role in diminishing epithelial cell membrane integrity through degradation of desmogelin-2 in breast cancer cells | Homo sapiens |