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Literature summary for 3.4.21.106 extracted from

  • Brunati, M.; Perucca, S.; Han, L.; Cattaneo, A.; Consolato, F.; Andolfo, A.; Schaeffer, C.; Olinger, E.; Peng, J.; Santambrogio, S.; Perrier, R.; Li, S.; Bokhove, M.; Bachi, A.; Hummler, E.; Devuyst, O.; Wu, Q.; Jovine, L.; Rampoldi, L.
    The serine protease hepsin mediates urinary secretion and polymerisation of Zona Pellucida domain protein uromodulin (2015), eLife, 4, e08887 .
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Mus musculus O35453
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Source Tissue

Source Tissue Comment Organism Textmining
kidney
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 Mus musculus
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General Information

General Information Comment Organism
physiological function membrane-bound hepsin is the enzyme responsible for the physiological cleavage of uromodulin, the most abundant protein in the urine. Hepsin physically interacts with uromodulin and cleaves at the physiological site in vitro and in vivo Mus musculus