Literature summary for 3.4.21.106 extracted from

Franco, F.M.; Jones, D.E.; Harris, P.K.; Han, Z.; Wildman, S.A.; Jarvis, C.M.; Janetka, J.W.
Structure-based discovery of small molecule hepsin and HGFA protease inhibitors Evaluation of potency and selectivity derived from distinct binding pockets (2015), Bioorg. Med. Chem., 23, 2328-2343 .

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Inhibitors

Inhibitors	Comment	Organism	Structure
(S)-N-(4-bromobenzyl)-4-(3-(3-carbamimidoylphenyl)-2-(naphthalene-2-sulfonamido)propanoyl)piperazine-1-carboxamide	inhibitor shows potency and selectivity for hepsin over matriptase and hepatocyte growth factor activator	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P05981	-	-

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.000045	-	pH not specified in the publication, temperature not specified in the publication	Homo sapiens	(S)-N-(4-bromobenzyl)-4-(3-(3-carbamimidoylphenyl)-2-(naphthalene-2-sulfonamido)propanoyl)piperazine-1-carboxamide

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Release 2023.1 (January 2023)