Organism | UniProt | Comment | Textmining |
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Mus musculus | O35453 | - |
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General Information | Comment | Organism |
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physiological function | deletion of hepsin in mice results in enlarged hepatocytes and narrowed liver sinusoids. Metastatic cancer cells preferentially colonize the hepsin-/- mouse liver as a result of the retention of tumor cells because of narrower sinusoids. The enlarged hepatocytes express increased levels of connexin, which results from defective prohepatocyte growth factor processing and decreased c-Met phosphorylation in the livers of hepsin-/- mice. Treatment of hepsin-/- mice with recombinant hepatocyte growth factor rescues these phenotypes, and treatment of wild-type mice with an hepatocyte growth fator antagonist recapitulates the phenotypes observed in hepsin-/- mice | Mus musculus |