Literature summary for 3.4.21.106 extracted from

Hsu, Y.C.; Huang, H.P.; Yu, I.S.; Su, K.Y.; Lin, S.R.; Lin, W.C.; Wu, H.L.; Shi, G.Y.; Tao, M.H.; Kao, C.H.; Wu, Y.M.; Martin, P.E.; Lin, S.Y.; Yang, P.C.; Lin, S.W.
Serine protease hepsin regulates hepatocyte size and hemodynamic retention of tumor cells by hepatocyte growth factor signaling in mice (2012), Hepatology, 56, 1913-1923.

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Organism

Organism	UniProt	Comment	Textmining
Mus musculus	O35453	-	-

General Information

General Information	Comment	Organism
physiological function	deletion of hepsin in mice results in enlarged hepatocytes and narrowed liver sinusoids. Metastatic cancer cells preferentially colonize the hepsin-/- mouse liver as a result of the retention of tumor cells because of narrower sinusoids. The enlarged hepatocytes express increased levels of connexin, which results from defective prohepatocyte growth factor processing and decreased c-Met phosphorylation in the livers of hepsin-/- mice. Treatment of hepsin-/- mice with recombinant hepatocyte growth factor rescues these phenotypes, and treatment of wild-type mice with an hepatocyte growth fator antagonist recapitulates the phenotypes observed in hepsin-/- mice	Mus musculus

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Release 2023.1 (January 2023)