Literature summary for 3.4.21.106 extracted from

Zhang, C.; Zhang, M.; Wu, Q.; Peng, J.; Ruan, Y.; Gu, J.
Hepsin inhibits CDK11p58 IRES activity by suppressing unr expression and eIF-2alpha phosphorylation in prostate cancer (2015), Cell. Signal., 27, 789-797.

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Cloned(Commentary)

Cloned (Comment)	Organism
expression in LNCaP and PC-3 cells	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P05981	-	-

General Information

General Information	Comment	Organism
physiological function	hepsin inhibits the internal ribosome entry site activity and expression of CDK11p58,which is associated with cell cycle progression and pro-apoptotic signaling in prostate cancer. Hepsin suppresses CDK11p58 internal ribosome entry site activity in prostate cancer by modulating transacting factor unr expression and eIF-2alpha phosphorylation. Hepsin inhibits the expression of unr by directly binding to unr internal ribosome entry site element and suppressing its activity, and also represses eIF-2alpha phosphorylation through down-regulating the expression and phosphorylation of general control nonderepressible-2	Homo sapiens

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Release 2023.1 (January 2023)