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Literature summary for 3.4.21.106 extracted from

  • Ganesan, R.; Kolumam, G.A.; Lin, S.J.; Xie, M.H.; Santell, L.; Wu, T.D.; Lazarus, R.A.; Chaudhuri, A.; Kirchhofer, D.
    Proteolytic activation of pro-macrophage-stimulating protein by hepsin (2011), Mol. Cancer Res., 9, 1175-1186.
    View publication on PubMed
Search for more literature for 3.4.21.106

Organism

Organism UniProt Comment Textmining
Homo sapiens
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Source Tissue

Source Tissue Comment Organism Textmining
LNCaP cell
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 Homo sapiens
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macrophage
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 Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
pro-macrophage-stimulating protein + H2O the cleavage site is between Arg(483) and Val(484). At least 50% of the substrate is processed within 1 h at a hepsin concentration of 2.4 nM and at a molar enzyme to substrate ratio of 1:500 Homo sapiens ?
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 ?

General Information

General Information Comment Organism
physiological function the macrophage-stimulating protein/RON signaling pathway is regulated by hepsin in tissue homeostasis and in disease pathologies, such as in cancer and immune disorders Homo sapiens