Literature summary for 3.4.21.106 extracted from

Koschubs, T.; Dengl, S.; Duerr, H.; Kaluza, K.; Georges, G.; Hartl, C.; Jennewein, S.; Lanzendoerfer, M.; Auer, J.; Stern, A.; Huang, K.S.; Packman, K.; Gubler, U.; Kostrewa, D.; Ries, S.; Hansen, S.; Kohnert, U.; Cramer, P.; Mundigl, O.
Allosteric antibody inhibition of human Hepsin protease (2012), Biochem. J., 442, 483-494.

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Cloned(Commentary)

Cloned (Comment)	Organism
expressed in FS-293 and HEK-293 cells	Homo sapiens

Crystallization (Commentary)

Crystallization (Comment)	Organism
hepsin in complex with antibody hH35, hanging drop vapor diffusion method, using 18% (w/v) PEG 3350, 0.15 M Mg2SO4 and 0.01 M BaCl2	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	antibody hH35 potently inhibits hepsin enzymatic activity at nanomolar concentrations, showing non-linear, slow, tight-binding inhibition	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
hepatocyte growth factor precursor + H2O	Homo sapiens	-	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P05981	-	-

Purification (Commentary)

Purification (Comment)	Organism
anti EE-antibody-protein G Sepharose column chromatography	Homo sapiens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
hepatocyte growth factor precursor + H2O	-	Homo sapiens	?	-	?
N-acetyl-KQLR-7-amido-4-methylcoumarin + H2O	-	Homo sapiens	N-acetyl-KQLR + 7-amino-4-methylcoumarin	-	?

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Release 2023.1 (January 2023)