Literature summary for 3.4.21.106 extracted from

Li, W.; Wang, B.E.; Moran, P.; Lipari, T.; Ganesan, R.; Corpuz, R.; Ludlam, M.J.; Gogineni, A.; Koeppen, H.; Bunting, S.; Gao, W.Q.; Kirchhofer, D.
Pegylated kunitz domain inhibitor suppresses hepsin-mediated invasive tumor growth and metastasis (2009), Cancer Res., 69, 8395-8402.

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Cloned(Commentary)

Cloned (Comment)	Organism
-	Mus musculus

Inhibitors

Inhibitors	Comment	Organism	Structure
PEGylated Kunitz domain-1	potent hepsin active site inhibitor derived from hepatocyte growth factor activator inhibitor-1	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Mus musculus

Source Tissue

Source Tissue	Comment	Organism	Textmining
LNCaP-17 cell	-	Mus musculus	-
LNCaP-34 cell	-	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
pro-hepatocyte growth factor + H2O	-	Mus musculus	active hepatocyte growth factor	-	?

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.00002	-	PEGylated Kunitz domain-1	apparent value	Mus musculus

General Information

General Information	Comment	Organism
physiological function	hepsin promotes invasive prostate tumor growth and metastasis	Mus musculus

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Release 2023.1 (January 2023)