Literature summary for 3.4.21.106 extracted from

Owen, K.A.; Qiu, D.; Alves, J.; Schumacher, A.M.; Kilpatrick, L.M.; Li, J.; Harris, J.L.; Ellis, V.
Pericellular activation of hepatocyte growth factor by the transmembrane serine proteases matriptase and hepsin, but not by the membrane-associated protease uPA (2010), Biochem. J., 426, 219-228.

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Cloned(Commentary)

Cloned (Comment)	Organism
expressed in LNCaP cells	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HEK-293 cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
hepatocyte growth factor precursor + H2O	the catalytic domain of hepsin is a highly efficient activator (50% activation at 3.4 nM) of hepatocyte growth factor, the optimal P4-P1 substrate preference for hepsin sequence is Lys-Gln-Leu-Arg which exactly matches the activation sequence of hepatocyte growth factor precursor	Homo sapiens	?	-	?
N-acetyl-L-Lys-L-Arg-L-Leu-L-Arg-7-amido-4-carbamoylmethylcoumarin + H2O	-	Homo sapiens	?	-	?

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Release 2023.1 (January 2023)