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Literature summary for 3.4.21.106 extracted from
- Hepsin inhibits the cell growth of endometrial cancer (2008), Int. J. Mol. Med., 22, 389-397.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | biological functions and effects of hepsin are analysed in vitro and in vivo, using endometrial cancer cell lines Ishikawa, HEC-1A, stably transfected with human hepsin. A significant inhibitory effect on cell growth in a monolayer culture system and in anchorage-independent cell growth in soft agar in vitro is observed. In a xenograft model, growth inhibitory effects are shown observed when compared with the effects of mock-transfected cells used as a control. Hepsin shows potential inhibitory effects mediated by the induction of 14-3-3sigma expression which leads to both cell cycle arrest at the G2/M phase through cyclin B and cyclin A and the p53-dependent pathway activated by increasing the level of Bak and reducing the level of Bcl-2 and Bcl-xL | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| hepsin | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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