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Literature summary for 3.4.21.106 extracted from

  • Miao, J.; Mu, D.; Ergel, B.; Singavarapu, R.; Duan, Z.; Powers, S.; Oliva, E.; Orsulic, S.
    Hepsin colocalizes with desmosomes and induces progression of ovarian cancer in a mouse model (2008), Int. J. Cancer, 123, 2041-2047.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
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Homo sapiens

Protein Variants

Protein Variants Comment Organism
H203A/D257A/S353A overexpression of catalytically inactive mutant hepsin abrogates its ability to induce tumor growth in a mouse model Homo sapiens
additional information overexpression of hepsin promotes ovarian tumor growth in a mouse model Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm hepsin is detected in the cytoplasm and membrane of hepatocytes. In ovarian tumor cells, cytoplasmic localization of hepsin is prevalent in mucinous, endometrioid and transitional cell carcinomas, while the majority of serous and clear cell carcinomas display membranous localization Homo sapiens 5737
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membrane hepsin is detected in the cytoplasm and membrane of hepatocytes. In ovarian tumor cells, cytoplasmic localization of hepsin is prevalent in mucinous, endometrioid and transitional cell carcinomas, while the majority of serous and clear cell carcinomas display membranous localization. Membrane-associated hepsin protein is present at desmosomal junctions, where it colocalizes with its putative proteolytic substrate hepatocyte growth factor Homo sapiens 16020
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Organism

Organism UniProt Comment Textmining
Homo sapiens P05981
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Source Tissue

Source Tissue Comment Organism Textmining
hepatocyte
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Homo sapiens
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ovary
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Homo sapiens
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ovary cancer cell in ovarian cancer hepsin expression is mainly confined to the epithelial cells and not the adjacent stroma Homo sapiens
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Synonyms

Synonyms Comment Organism
hepsin
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Homo sapiens