Cloned (Comment) | Organism |
---|---|
- |
Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
H203A/D257A/S353A | overexpression of catalytically inactive mutant hepsin abrogates its ability to induce tumor growth in a mouse model | Homo sapiens |
additional information | overexpression of hepsin promotes ovarian tumor growth in a mouse model | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | hepsin is detected in the cytoplasm and membrane of hepatocytes. In ovarian tumor cells, cytoplasmic localization of hepsin is prevalent in mucinous, endometrioid and transitional cell carcinomas, while the majority of serous and clear cell carcinomas display membranous localization | Homo sapiens | 5737 | - |
membrane | hepsin is detected in the cytoplasm and membrane of hepatocytes. In ovarian tumor cells, cytoplasmic localization of hepsin is prevalent in mucinous, endometrioid and transitional cell carcinomas, while the majority of serous and clear cell carcinomas display membranous localization. Membrane-associated hepsin protein is present at desmosomal junctions, where it colocalizes with its putative proteolytic substrate hepatocyte growth factor | Homo sapiens | 16020 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P05981 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
hepatocyte | - |
Homo sapiens | - |
ovary | - |
Homo sapiens | - |
ovary cancer cell | in ovarian cancer hepsin expression is mainly confined to the epithelial cells and not the adjacent stroma | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
hepsin | - |
Homo sapiens |