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Literature summary for 3.4.21.106 extracted from

  • Nakamura, K.; Nasu, Y.; Hongo, A.; Matsuo, T.; Kodama, J.; Ebara, S.; Nagai, A.; Abrzua, F.; Kumon, H.; Hiramatsu, Y.
    Hepsin shows inhibitory effects through apoptotic pathway on ovarian cancer cell lines (2006), Int. J. Oncol., 28, 393-398.
    View publication on PubMed
Search for more literature for 3.4.21.106

Application

Application Comment Organism
medicine hepsin significantly inhibits cell growth in the monolayer, anchorage-independent cell growth in soft agar in vitro, and tumorigenicity in vivo in ovarian cancer cell lines, through up-regulation of p53-dependent apoptosis and caspase-3, -6, and -7 activations Homo sapiens
medicine hepsin has a potential therapeutic effect that inhibits through upregulation of p53-dependent apoptosis and caspase-3, -6, and -7 activations. Hepsin may be useful in ovarian cancer treatment Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
full-length hepsin cDNA construct transiently transfected in BG-1 cell lines. Hepsin stable transfectant BG-1 cells injected in nude mice Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
BG-1 cell strongest transformation on anchorage-independent cell growth Homo sapiens
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BG-1 cell transient transfection of hepsin increases the progress of apoptosis/supresses proliferation. Inhibition of cell growth in monolayer culture. Increased accumulation of p53-dependent apoptosis and caspases-3, -6, and -7 in stabley transfected BG-1 cells Homo sapiens
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CAOV-3 cell
-
 Homo sapiens
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epithelial cell
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 Homo sapiens
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LNCaP cell
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 Homo sapiens
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LNCaP cell used as positive control Homo sapiens
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ovary cancer cell line
-
 Homo sapiens
-
OVCAR-3 cell
-
 Homo sapiens
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prostate cancer cell line used as positive control Homo sapiens
-

Synonyms

Synonyms Comment Organism
type II transmembrane serine protease
-
 Homo sapiens