Literature summary for 3.4.21.106 extracted from

Kirchhofer, D.; Peek, M.; Lipari, M.T.; Billeci, K.; Fan, B.; Moran, P.
Hepsin activates pro-hepatocyte growth factor and is inhibited by hepatocyte growth factor activator inhibitor-1B (HAI-1B) and HAI-2 (2005), FEBS Lett., 579, 1945-1950.

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Application

Application	Comment	Organism
medicine	hepsin is a potent activator of pro-hepatocyte growth factor, thus contributing to tumor progression	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
cDNA of full lenth hepsin inserted into vector pRK5E, His-tagged hepsin cDNA inserted into vector pCMV.PD5, expression in a chinese hamster ovary expression system	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
hepatocyte growth factor activator inhibitor-1B	potent inhibitor of hepsin	Homo sapiens
hepatocyte growth factor activator inhibitor-2	potent inhibitor of hepsin	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P05981	-	-

Purification (Commentary)

Purification (Comment)	Organism
by Ni-affinity chromatography	Homo sapiens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
S2366 + H2O	-	Homo sapiens	?	-	?
single-chain hepatocyte growth factor + H2O	efficiently converted by soluble form of hepsin comprising the entire extracellular domain	Homo sapiens	two-chain hepatocyte growth factor	-	?

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.001	-	hepatocyte growth factor activator inhibitor-2	completely inhibits	Homo sapiens
0.001	-	hepatocyte growth factor activator inhibitor-1B	completely inhibits	Homo sapiens

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Release 2023.1 (January 2023)