Literature summary for 3.4.21.106 extracted from

Zhang, J.L.; Zhao, W.G.; Wu, K.L.; Wang, K.; Zhang, X.; Gu, C.F.; Li, Y.; Zhu, Y.; Wu, J.G.
Human hepatitis B virus X protein promotes cell proliferation and inhibits cell apoptosis through interacting with a serine protease hepsin (2005), Arch. Virol., 150, 721-741.

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Application

Application	Comment	Organism
medicine	human hepsin interacts directly with X protein of human hepatitis B virus both in vitro and in vivo, their interaction appears to play a role in both promoting cell proliferation and blocking apoptosis in human liver tumor cell and normal liver cell lines, promotes expression of viral protein HBeAg in Hep-G2.2.1.5 cells, thus stimulating viral replication	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
cloned into vector pCMV-HA and vector pCMV-flag	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P05981	chinese patient with hepatocellular carcinoma combined hepatitis B virus infection, strain WhuTJ-37	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
Hep-G2 cell	-	Homo sapiens	-
liver cancer cell	-	Homo sapiens	-
liver cell line	-	Homo sapiens	-
additional information	Hep-G2.2.1.5 cell and L-02 cell	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
transmembrane serine protease 1	-	Homo sapiens

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Release 2023.1 (January 2023)