Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli C43(DE3) cells | Escherichia coli |
expressed in Escherichia coli C43(DE3) cells | Providencia stuartii |
Protein Variants | Comment | Organism |
---|---|---|
S150A | inactive | Providencia stuartii |
S201A | inactive | Escherichia coli |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(3S,4S)-1-[(4-chlorophenyl)sulfonyl]-3-methyl-4-phenylazetidin-2-one | - |
Escherichia coli | |
(3S,4S)-1-[(4-chlorophenyl)sulfonyl]-3-methyl-4-phenylazetidin-2-one | - |
Providencia stuartii | |
(3S,4S)-3-methyl-1-[(4-methylphenyl)sulfonyl]-4-phenylazetidin-2-one | - |
Providencia stuartii | |
1-(2,3-dihydro-4H-1,4-benzoxazin-4-yl)-3,3,3-trifluoro-2-(trifluoromethyl)propan-1-one | - |
Escherichia coli | |
1-(2,3-dihydro-4H-1,4-benzoxazin-4-yl)-3,3,3-trifluoro-2-(trifluoromethyl)propan-1-one | - |
Providencia stuartii | |
1-(biphenyl-3-ylsulfonyl)-4-phenylazetidin-2-one | - |
Escherichia coli | |
1-(biphenyl-3-ylsulfonyl)-4-phenylazetidin-2-one | - |
Providencia stuartii | |
1-(biphenyl-4-ylsulfonyl)-4-phenylazetidin-2-one | - |
Escherichia coli | |
1-(biphenyl-4-ylsulfonyl)-4-phenylazetidin-2-one | - |
Providencia stuartii | |
1-[(3'-methylbiphenyl-4-yl)sulfonyl]-4-phenylazetidin-2-one | - |
Escherichia coli | |
1-[(3'-methylbiphenyl-4-yl)sulfonyl]-4-phenylazetidin-2-one | - |
Providencia stuartii | |
1-[(3-bromophenyl)sulfonyl]-4-phenylazetidin-2-one | - |
Escherichia coli | |
1-[(3-bromophenyl)sulfonyl]-4-phenylazetidin-2-one | - |
Providencia stuartii | |
1-[(3-chlorophenyl)sulfonyl]-4-(2-phenylethyl)azetidin-2-one | - |
Escherichia coli | |
1-[(3-chlorophenyl)sulfonyl]-4-(2-phenylethyl)azetidin-2-one | - |
Providencia stuartii | |
1-[(3-chlorophenyl)sulfonyl]-4-(propan-2-yl)azetidin-2-one | - |
Escherichia coli | |
1-[(3-chlorophenyl)sulfonyl]-4-(propan-2-yl)azetidin-2-one | - |
Providencia stuartii | |
1-[(4'-chlorobiphenyl-4-yl)sulfonyl]-4-phenylazetidin-2-one | - |
Escherichia coli | |
1-[(4'-chlorobiphenyl-4-yl)sulfonyl]-4-phenylazetidin-2-one | - |
Providencia stuartii | |
1-[(4-bromophenyl)sulfonyl]-4-phenylazetidin-2-one | - |
Escherichia coli | |
1-[(4-bromophenyl)sulfonyl]-4-phenylazetidin-2-one | - |
Providencia stuartii | |
1-[(4-chlorophenyl)sulfonyl]-3-methylazetidin-2-one | - |
Escherichia coli | |
1-[(4-chlorophenyl)sulfonyl]-3-methylazetidin-2-one | - |
Providencia stuartii | |
1-[(4-methylphenyl)sulfonyl]-4-phenylazetidin-2-one | - |
Escherichia coli | |
1-[(4-methylphenyl)sulfonyl]-4-phenylazetidin-2-one | - |
Providencia stuartii | |
3,3,3-trifluoro-N-[(5-methyl-2-phenyl-2H-1,2,3-triazol-4-yl)methyl]-2-(trifluoromethyl)propanamide | - |
Escherichia coli | |
3,3,3-trifluoro-N-[(5-methyl-2-phenyl-2H-1,2,3-triazol-4-yl)methyl]-2-(trifluoromethyl)propanamide | - |
Providencia stuartii | |
3,3,3-trifluoro-N-[2-(propan-2-yloxy)phenyl]-2-(trifluoromethyl)propanamide | - |
Escherichia coli | |
3,3,3-trifluoro-N-[2-(propan-2-yloxy)phenyl]-2-(trifluoromethyl)propanamide | - |
Providencia stuartii | |
3-methyl-1-[(4-methylphenyl)sulfonyl]-4-phenylazetidin-2-one | - |
Escherichia coli | |
4-(2-chlorophenyl)-1-[(3-chlorophenyl)sulfonyl]azetidin-2-one | - |
Escherichia coli | |
4-(2-chlorophenyl)-1-[(3-chlorophenyl)sulfonyl]azetidin-2-one | - |
Providencia stuartii | |
4-(3-bromophenyl)-1-[(3-chlorophenyl)sulfonyl]azetidin-2-one | - |
Escherichia coli | |
4-(3-bromophenyl)-1-[(3-chlorophenyl)sulfonyl]azetidin-2-one | - |
Providencia stuartii | |
4-[(3-methyl-2-oxoazetidin-1-yl)sulfonyl]benzonitrile | - |
Escherichia coli | |
4-[(3-methyl-2-oxoazetidin-1-yl)sulfonyl]benzonitrile | - |
Providencia stuartii | |
benzyl (2S)-1-[(4-methylphenyl)sulfonyl]-4-oxoazetidine-2-carboxylate | - |
Escherichia coli | |
benzyl (2S)-1-[(4-methylphenyl)sulfonyl]-4-oxoazetidine-2-carboxylate | - |
Providencia stuartii | |
N-(2,6-dimethylphenyl)-3,3,3-trifluoro-2-(trifluoromethyl)propanamide | - |
Escherichia coli | |
N-(2,6-dimethylphenyl)-3,3,3-trifluoro-2-(trifluoromethyl)propanamide | - |
Providencia stuartii | |
N-[2-(cyclopentyloxy)phenyl]-3,3,3-trifluoro-2-(trifluoromethyl)propanamide | - |
Escherichia coli | |
N-[2-(cyclopentyloxy)phenyl]-3,3,3-trifluoro-2-(trifluoromethyl)propanamide | - |
Providencia stuartii | |
N-[2-(cyclopropylmethoxy)phenyl]-3,3,3-trifluoro-2-(trifluoromethyl)propanamide | - |
Escherichia coli | |
N-[2-(cyclopropylmethoxy)phenyl]-3,3,3-trifluoro-2-(trifluoromethyl)propanamide | - |
Providencia stuartii | |
phenyl 2-oxo-4-phenylazetidine-1-carboxylate | - |
Escherichia coli | |
phenyl 2-oxo-4-phenylazetidine-1-carboxylate | - |
Providencia stuartii | |
tert-butyl 2-[[3,3,3-trifluoro-2-(trifluoromethyl)propanoyl]amino]benzoate | - |
Escherichia coli | |
tert-butyl 2-[[3,3,3-trifluoro-2-(trifluoromethyl)propanoyl]amino]benzoate | - |
Providencia stuartii |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Gurken protein + H2O | Escherichia coli | - |
PQRKVRMA + HIVFSFFV | - |
? | |
Gurken protein + H2O | Providencia stuartii | - |
PQRKVRMA + HIVFSFFV | - |
? | |
Gurken protein + H2O | Escherichia coli NR698 | - |
PQRKVRMA + HIVFSFFV | - |
? | |
LacYTM2 protein + H2O | Escherichia coli | - |
DINHISKS + DTGIIFAA | - |
? | |
LacYTM2 protein + H2O | Providencia stuartii | - |
DINHISKS + DTGIIFAA | - |
? | |
LacYTM2 protein + H2O | Escherichia coli NR698 | - |
DINHISKS + DTGIIFAA | - |
? | |
TatA protein + H2O | Escherichia coli | - |
MESTIATA + AFGSPWQL | - |
? | |
TatA protein + H2O | Providencia stuartii | - |
MESTIATA + AFGSPWQL | - |
? | |
TatA protein + H2O | Escherichia coli NR698 | - |
MESTIATA + AFGSPWQL | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Escherichia coli NR698 | - |
- |
- |
Providencia stuartii | - |
- |
- |
Purification (Comment) | Organism |
---|---|
His-Pure Cobalt affinity column chromatography | Escherichia coli |
His-Pure Cobalt affinity column chromatography | Providencia stuartii |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Gurken protein + H2O | - |
Escherichia coli | PQRKVRMA + HIVFSFFV | - |
? | |
Gurken protein + H2O | - |
Providencia stuartii | PQRKVRMA + HIVFSFFV | - |
? | |
Gurken protein + H2O | - |
Escherichia coli NR698 | PQRKVRMA + HIVFSFFV | - |
? | |
LacYTM2 protein + H2O | - |
Escherichia coli | DINHISKS + DTGIIFAA | - |
? | |
LacYTM2 protein + H2O | - |
Providencia stuartii | DINHISKS + DTGIIFAA | - |
? | |
LacYTM2 protein + H2O | - |
Escherichia coli NR698 | DINHISKS + DTGIIFAA | - |
? | |
N-acetyl-PEG4-QRKVRMAHIVFSFPC-amide + H2O | i.e. peptide KSp21 | Escherichia coli | N-acetyl-PEG4-QRKVRMA + HIVFSFPC-amide | - |
? | |
N-acetyl-PEG4-QRKVRMAHIVFSFPC-amide + H2O | i.e. peptide KSp21 | Providencia stuartii | N-acetyl-PEG4-QRKVRMA + HIVFSFPC-amide | - |
? | |
N-acetyl-PEG4-QRKVRMAHIVFSFPC-amide + H2O | i.e. peptide KSp21 | Escherichia coli NR698 | N-acetyl-PEG4-QRKVRMA + HIVFSFPC-amide | - |
? | |
TatA protein + H2O | - |
Escherichia coli | MESTIATA + AFGSPWQL | - |
? | |
TatA protein + H2O | - |
Providencia stuartii | MESTIATA + AFGSPWQL | - |
? | |
TatA protein + H2O | - |
Escherichia coli NR698 | MESTIATA + AFGSPWQL | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AarA | - |
Providencia stuartii |
GlpG | - |
Escherichia coli |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.001 | - |
25 mM HEPES, pH 7.4, 5 mM EDTA, 5% (v/v) glycerol, 0.5% (w/v) DDM, 20% (v/v) DMSO, at 25°C | Providencia stuartii | N-[2-(cyclopropylmethoxy)phenyl]-3,3,3-trifluoro-2-(trifluoromethyl)propanamide | |
0.0013 | - |
25 mM HEPES, pH 7.4, 5 mM EDTA, 5% (v/v) glycerol, 0.5% (w/v) DDM, 20% (v/v) DMSO, at 25°C | Providencia stuartii | tert-butyl 2-[[3,3,3-trifluoro-2-(trifluoromethyl)propanoyl]amino]benzoate | |
0.0018 | - |
25 mM HEPES, pH 7.4, 5 mM EDTA, 5% (v/v) glycerol, 0.5% (w/v) DDM, 20% (v/v) DMSO, at 25°C | Providencia stuartii | N-[2-(cyclopentyloxy)phenyl]-3,3,3-trifluoro-2-(trifluoromethyl)propanamide | |
0.0023 | - |
25 mM HEPES, pH 7.4, 5 mM EDTA, 5% (v/v) glycerol, 0.5% (w/v) DDM, 20% (v/v) DMSO, at 25°C | Providencia stuartii | 3,3,3-trifluoro-N-[2-(propan-2-yloxy)phenyl]-2-(trifluoromethyl)propanamide | |
0.0033 | - |
25 mM HEPES, pH 7.4, 5 mM EDTA, 5% (v/v) glycerol, 0.5% (w/v) DDM, 20% (v/v) DMSO, at 25°C | Providencia stuartii | 3,3,3-trifluoro-N-[(5-methyl-2-phenyl-2H-1,2,3-triazol-4-yl)methyl]-2-(trifluoromethyl)propanamide | |
0.0038 | - |
25 mM HEPES, pH 7.4, 5 mM EDTA, 5% (v/v) glycerol, 0.5% (w/v) DDM, 20% (v/v) DMSO, at 25°C | Providencia stuartii | 1-(2,3-dihydro-4H-1,4-benzoxazin-4-yl)-3,3,3-trifluoro-2-(trifluoromethyl)propan-1-one | |
0.0068 | - |
25 mM HEPES, pH 7.4, 5 mM EDTA, 5% (v/v) glycerol, 0.5% (w/v) DDM, 20% (v/v) DMSO, at 25°C | Providencia stuartii | 4-(3-bromophenyl)-1-[(3-chlorophenyl)sulfonyl]azetidin-2-one | |
0.014 | - |
25 mM HEPES, pH 7.4, 5 mM EDTA, 5% (v/v) glycerol, 0.5% (w/v) DDM, 20% (v/v) DMSO, at 25°C | Providencia stuartii | 1-(biphenyl-3-ylsulfonyl)-4-phenylazetidin-2-one | |
0.016 | - |
25 mM HEPES, pH 7.4, 5 mM EDTA, 5% (v/v) glycerol, 0.5% (w/v) DDM, 20% (v/v) DMSO, at 25°C | Providencia stuartii | 1-[(3-bromophenyl)sulfonyl]-4-phenylazetidin-2-one | |
0.017 | - |
25 mM HEPES, pH 7.4, 5 mM EDTA, 5% (v/v) glycerol, 0.5% (w/v) DDM, 20% (v/v) DMSO, at 25°C | Providencia stuartii | N-(2,6-dimethylphenyl)-3,3,3-trifluoro-2-(trifluoromethyl)propanamide | |
0.0183 | - |
25 mM HEPES, pH 7.4, 5 mM EDTA, 5% (v/v) glycerol, 0.5% (w/v) DDM, 20% (v/v) DMSO, at 25°C | Providencia stuartii | 4-(2-chlorophenyl)-1-[(3-chlorophenyl)sulfonyl]azetidin-2-one | |
0.02 | - |
25 mM HEPES, pH 7.4, 5 mM EDTA, 5% (v/v) glycerol, 0.5% (w/v) DDM, 20% (v/v) DMSO, at 25°C | Providencia stuartii | 4-[(3-methyl-2-oxoazetidin-1-yl)sulfonyl]benzonitrile | |
0.026 | - |
25 mM HEPES, pH 7.4, 5 mM EDTA, 5% (v/v) glycerol, 0.5% (w/v) DDM, 20% (v/v) DMSO, at 25°C | Providencia stuartii | 1-[(4-bromophenyl)sulfonyl]-4-phenylazetidin-2-one | |
0.026 | - |
25 mM HEPES, pH 7.4, 5 mM EDTA, 5% (v/v) glycerol, 0.5% (w/v) DDM, 20% (v/v) DMSO, at 25°C | Providencia stuartii | 1-[(4-chlorophenyl)sulfonyl]-3-methylazetidin-2-one | |
0.029 | - |
25 mM HEPES, pH 7.4, 5 mM EDTA, 5% (v/v) glycerol, 0.5% (w/v) DDM, 20% (v/v) DMSO, at 25°C | Providencia stuartii | benzyl (2S)-1-[(4-methylphenyl)sulfonyl]-4-oxoazetidine-2-carboxylate | |
0.03 | - |
25 mM HEPES, pH 7.4, 5 mM EDTA, 5% (v/v) glycerol, 0.5% (w/v) DDM, 20% (v/v) DMSO, at 25°C | Providencia stuartii | (3S,4S)-3-methyl-1-[(4-methylphenyl)sulfonyl]-4-phenylazetidin-2-one | |
0.033 | - |
25 mM HEPES, pH 7.4, 5 mM EDTA, 5% (v/v) glycerol, 0.5% (w/v) DDM, 20% (v/v) DMSO, at 25°C | Providencia stuartii | 1-[(3-chlorophenyl)sulfonyl]-4-(2-phenylethyl)azetidin-2-one | |
0.041 | - |
25 mM HEPES, pH 7.4, 5 mM EDTA, 5% (v/v) glycerol, 0.5% (w/v) DDM, 20% (v/v) DMSO, at 25°C | Providencia stuartii | 1-(biphenyl-4-ylsulfonyl)-4-phenylazetidin-2-one | |
0.043 | - |
25 mM HEPES, pH 7.4, 5 mM EDTA, 5% (v/v) glycerol, 0.5% (w/v) DDM, 20% (v/v) DMSO, at 25°C | Providencia stuartii | 1-[(3'-methylbiphenyl-4-yl)sulfonyl]-4-phenylazetidin-2-one | |
0.047 | - |
25 mM HEPES, pH 7.4, 5 mM EDTA, 5% (v/v) glycerol, 0.5% (w/v) DDM, 20% (v/v) DMSO, at 25°C | Providencia stuartii | 1-[(4'-chlorobiphenyl-4-yl)sulfonyl]-4-phenylazetidin-2-one | |
0.07 | - |
25 mM HEPES, pH 7.4, 5 mM EDTA, 5% (v/v) glycerol, 0.5% (w/v) DDM, 20% (v/v) DMSO, at 25°C | Providencia stuartii | (3S,4S)-1-[(4-chlorophenyl)sulfonyl]-3-methyl-4-phenylazetidin-2-one | |
0.074 | - |
25 mM HEPES, pH 7.4, 5 mM EDTA, 5% (v/v) glycerol, 0.5% (w/v) DDM, 20% (v/v) DMSO, at 25°C | Providencia stuartii | 1-[(4-methylphenyl)sulfonyl]-4-phenylazetidin-2-one | |
0.085 | - |
25 mM HEPES, pH 7.4, 5 mM EDTA, 5% (v/v) glycerol, 0.5% (w/v) DDM, 20% (v/v) DMSO, at 25°C | Providencia stuartii | 1-[(3-chlorophenyl)sulfonyl]-4-(propan-2-yl)azetidin-2-one | |
0.182 | - |
25 mM HEPES, pH 7.4, 5 mM EDTA, 5% (v/v) glycerol, 0.5% (w/v) DDM, 20% (v/v) DMSO, at 25°C | Providencia stuartii | phenyl 2-oxo-4-phenylazetidine-1-carboxylate |