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Literature summary for 3.4.21.105 extracted from

  • Del Rio, A.; Dutta, K.; Chavez, J.; Ubarretxena-Belandia, I.; Ghose, R.
    Solution structure and dynamics of the N-terminal cytosolic domain of rhomboid intramembrane protease from Pseudomonas aeruginosa: insights into a functional role in intramembrane proteolysis (2007), J. Mol. Biol., 365, 109-122.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane the intramembrane enzyme possesses an N-terminal cytosolic domain, solution structure and dynamics, membrane protein topology, overview Pseudomonas aeruginosa 16020
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Pseudomonas aeruginosa Rhomboids are ubiquitous integral membrane proteases that release cellular signals from membrane-bound substrates through a general signal transduction mechanism known as regulated intramembrane proteolysis ?
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?

Organism

Organism UniProt Comment Textmining
Pseudomonas aeruginosa
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information Rhomboids are ubiquitous integral membrane proteases that release cellular signals from membrane-bound substrates through a general signal transduction mechanism known as regulated intramembrane proteolysis Pseudomonas aeruginosa ?
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?
additional information the N-terminal cytosolic domain NRho plays a role in scissile peptide bond selectivity by optimally positioning the Rhomboid active site relative to the membrane plane Pseudomonas aeruginosa ?
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?

Subunits

Subunits Comment Organism
More the intramembrane enzyme possesses an N-terminal cytosolic domain NRho consisting of an alpha/beta fold, solution NMR structure and dynamics, structural plasticity may facilitate the ability of NRho to recognize and associate with membranes, membrane protein topology, overview Pseudomonas aeruginosa

Synonyms

Synonyms Comment Organism
rhomboid intramembrane protease
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Pseudomonas aeruginosa