Cloned (Comment) | Organism |
---|---|
phylogenetic analysis | Homo sapiens |
phylogenetic analysis | Saccharomyces cerevisiae |
seven rhomboid genes | Drosophila melanogaster |
Protein Variants | Comment | Organism |
---|---|---|
additional information | enzyme knockout strains show no phenotype | Bacillus subtilis |
additional information | enzyme knockout strains show no phenotype | Escherichia coli |
additional information | pcp1-deleted cells has a slow growth phenotype and contain unprocessed Mgm1 | Saccharomyces cerevisiae |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
Golgi apparatus | - |
Arabidopsis thaliana | 5794 | - |
Golgi membrane | intramembrane enzyme | Arabidopsis thaliana | 139 | - |
membrane | intramembrane enzyme with seven transmembrane segments, the enzyme contains a serine proteaselike catalytic apparatus embedded within the membrane bilayer, buried in a hydrophilic cavity formed by a protein ring | Drosophila melanogaster | 16020 | - |
mitochondrion | Rbd1 and Ygr101w | Saccharomyces cerevisiae | 5739 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
cytochrome c peroxidase + H2O | Saccharomyces cerevisiae | cleaving the targeting sequence of cytochrome c peroxidase, Pcp1 | processed cytochrome c peroxidase + targeting sequence peptide | - |
? | |
growth factor Spitz + H2O | Arabidopsis thaliana | - |
? | - |
? | |
growth factor Spitz + H2O | Drosophila melanogaster | Rhomboid-1 is important in extracellular signal production, overview | ? | - |
? | |
Mgm1 + H2O | Saccharomyces cerevisiae | cleaving the long isoform of Mgm1 to produce the short one | ? | - |
? | |
additional information | Drosophila melanogaster | Rhomboid is the signal-generating component of epidermal growth factor receptor signaling during development, a metazoan developmental regulator, intramembrane proteolysis is a widespread regulatory mechanism, overview, Rhomboid-3 is important in eye development | ? | - |
? | |
additional information | Bacillus subtilis | the enzyme is important in cell signaling, mechanism, overview | ? | - |
? | |
additional information | Escherichia coli | the enzyme is important in cell signaling, mechanism, overview | ? | - |
? | |
additional information | Homo sapiens | the enzyme is important in cell signaling, mechanism, overview | ? | - |
? | |
additional information | Saccharomyces cerevisiae | the enzyme is important in cell signaling, mechanism, overview | ? | - |
? | |
additional information | Providencia stuartii | the enzyme is important in cell signaling, mechanism, overview | ? | - |
? | |
additional information | Toxoplasma gondii | the enzyme proteolytically cleaves adhesin-receptor complexes during parasite invasion, overview, the enzyme is important in cell sigaling, mechanism, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Arabidopsis thaliana | - |
contains over a dozen rhomboid-like genes | - |
Bacillus subtilis | - |
- |
- |
Drosophila melanogaster | - |
rhomboid gene | - |
Escherichia coli | - |
gene glpG | - |
Homo sapiens | - |
- |
- |
Providencia stuartii | - |
Gram-negative human pathogen of the urinary tract, gene aarA | - |
Saccharomyces cerevisiae | - |
- |
- |
Toxoplasma gondii | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
eye | Rhomboid-3 | Drosophila melanogaster | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
cytochrome c peroxidase + H2O | cleaving the targeting sequence of cytochrome c peroxidase, Pcp1 | Saccharomyces cerevisiae | processed cytochrome c peroxidase + targeting sequence peptide | - |
? | |
growth factor Spitz + H2O | - |
Arabidopsis thaliana | ? | - |
? | |
growth factor Spitz + H2O | Rhomboid-1 | Drosophila melanogaster | ? | - |
? | |
growth factor Spitz + H2O | Rhomboid-1 is important in extracellular signal production, overview | Drosophila melanogaster | ? | - |
? | |
Mgm1 + H2O | cleaving the long isoform of Mgm1 to produce the short one | Saccharomyces cerevisiae | ? | - |
? | |
additional information | Rhomboid is the signal-generating component of epidermal growth factor receptor signaling during development, a metazoan developmental regulator, intramembrane proteolysis is a widespread regulatory mechanism, overview, Rhomboid-3 is important in eye development | Drosophila melanogaster | ? | - |
? | |
additional information | the enzyme is important in cell signaling, mechanism, overview | Bacillus subtilis | ? | - |
? | |
additional information | the enzyme is important in cell signaling, mechanism, overview | Escherichia coli | ? | - |
? | |
additional information | the enzyme is important in cell signaling, mechanism, overview | Homo sapiens | ? | - |
? | |
additional information | the enzyme is important in cell signaling, mechanism, overview | Saccharomyces cerevisiae | ? | - |
? | |
additional information | the enzyme is important in cell signaling, mechanism, overview | Providencia stuartii | ? | - |
? | |
additional information | the enzyme proteolytically cleaves adhesin-receptor complexes during parasite invasion, overview, the enzyme is important in cell sigaling, mechanism, overview | Toxoplasma gondii | ? | - |
? | |
additional information | PARL interacts with Alzheimers presenilin protein in vitro | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AarA | - |
Providencia stuartii |
GlpG | - |
Escherichia coli |
PARL | - |
Homo sapiens |
PARL | - |
Saccharomyces cerevisiae |
Pcp1 | - |
Saccharomyces cerevisiae |
presenilin-associated rhomboid-like | - |
Homo sapiens |
presenilin-associated rhomboid-like | - |
Saccharomyces cerevisiae |
Rbd1 | - |
Saccharomyces cerevisiae |
RHBDL | - |
Homo sapiens |
Rhomboid protein | - |
Drosophila melanogaster |
rhomboid-1 | - |
Drosophila melanogaster |
rhomboid-2 | - |
Drosophila melanogaster |
rhomboid-3 | - |
Drosophila melanogaster |
rhomboid-like protein | - |
Bacillus subtilis |
rhomboid-like protein | - |
Escherichia coli |
rhomboid-like protein | - |
Homo sapiens |
rhomboid-like protein | - |
Saccharomyces cerevisiae |
rhomboid-like protein | - |
Arabidopsis thaliana |
rhomboid-like protein | - |
Providencia stuartii |
rhomboid-like protein | - |
Toxoplasma gondii |
Spitz protease | - |
Drosophila melanogaster |
Ygr101w | - |
Saccharomyces cerevisiae |