Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q91WP0 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
MASP2 | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
physiological function | effect of MASP-2 deficiency in an isogenic mouse model of renal transplantation. Wild-type kidneys grafted into wild-type recipients develop acute renal failure. Wild-type grafts transplanted into MASP-2-deficient recipients show significantly better kidney function, less C3 deposition, and less ischemia reperfusion injury. In the absence of donor or recipient complement C4, the wild-type to wild-type phenotype is preserved, indicating that the MASP-2-mediated damage is independent of C4 activation. In mice deficient for both MASP-2 and C4, the protection from postoperative acute renal failure is no greater than in mice with MASP-2 deficiency alone. Injury occurs through MASP-2-dependent activation events independent of C4 | Mus musculus |