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Literature summary for 3.4.21.104 extracted from

  • Kocsis, A.; Kekesi, K.A.; Szasz, R.; Vegh, B.M.; Balczer, J.; Dobo, J.; Zavodszky, P.; Gal, P.; Pal, G.
    Selective inhibition of the lectin pathway of complement with phage display selected peptides against mannose-binding lectin-associated serine protease (MASP)-1 and -2: significant contribution of MASP-1 to lectin pathway activation (2010), J. Immunol., 185, 4169-4178.
    View publication on PubMed
Search for more literature for 3.4.21.104

Cloned(Commentary)

Cloned (Comment) Organism
-
 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
cyclic sunflower MASP inhibitor-1
-
 Homo sapiens
additional information MASP-2 is not inhibited by SFTI Homo sapiens
sunflower MASP inhibitor-1 i.e. GICSRSLPPICIPD Homo sapiens
sunflower MASP inhibitor-2 i.e. GYCSRSYPPYCIPD Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens MASP-2 has all the activities required for lectin pathway activation, it can autoactivate and cleave both complement components C4 and C2 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
serum
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
complement component C4 + H2O
-
 Homo sapiens ?
-
 ?
additional information MASP-2 has all the activities required for lectin pathway activation, it can autoactivate and cleave both complement components C4 and C2 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
mannose-binding lectin-associated serine protease 2
-
 Homo sapiens
MASP-2
-
 Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00018
-
 sunflower MASP inhibitor-2 in 20 mM HEPES, 140 mM NaCl, and 10 mM CaCl2 (pH 7.4), at 37°C Homo sapiens
0.00075
-
 cyclic sunflower MASP inhibitor-1 in 20 mM HEPES, 140 mM NaCl, and 10 mM CaCl2 (pH 7.4), at 37°C Homo sapiens
0.00103
-
 sunflower MASP inhibitor-1 in 20 mM HEPES, 140 mM NaCl, and 10 mM CaCl2 (pH 7.4), at 37°C Homo sapiens