Literature summary for 3.4.21.104 extracted from

Zehnder, A.; Fisch, U.; Hirt, A.; Niggli, F.K.; Simon, A.; Ozsahin, H.; Schlapbach, L.J.; Ammann, R.A.
Prognosis in pediatric hematologic malignancies is associated with serum concentration of mannose-binding lectin-associated serine protease-2 (MASP-2) (2009), Pediatr. Blood Cancer, 53, 53-57.

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Application

Application	Comment	Organism
medicine	it is investigated whether the concentration of mannose-binding lectin and MASP-2 is associated with prognosis in pediatric patients with cancer. In the 372 patients studied, median serum concentration of mannose-binding lectin (MBL) is 2.808 mg/l and 391 mg/l for MASP-2. The estimated 4-year event-free survival is 0.60. In the entire, heterogeneous sample, MBL and MASP-2 are not significantly associated with overall survival or event-free survival. In patients with hematologic malignancies, higher MASP-2 is associated with better event-free survival in a significant and clinically relevant way. This is due to patients with lymphoma, but less for those with acute leukemia	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
serum	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
MASP2	-	Homo sapiens

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Release 2023.1 (January 2023)