Literature summary for 3.4.21.104 extracted from

Hamad, I.; Hunter, A.C.; Szebeni, J.; Moghimi, S.M.
Poly(ethylene glycol)s generate complement activation products in human serum through increased alternative pathway turnover and a MASP-2-dependent process (2008), Mol. Immunol., 46, 225-232.

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Application

Application	Comment	Organism
molecular biology	near monodisperse endotoxin-free polyethylene glycol, at concentrations relevant to therapeutic effects, trigger complement activation in human sera. Depending on polyethylene glycol concentration and average molecular weight, complement activation proceeds either exclusively through MASP-2 activation, and a likely role for the lectin pathway, or through both MASP-2-mediated C4 cleavage and accelerated alternative pathway turnover	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
serum	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
MASP-2	-	Homo sapiens

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Release 2023.1 (January 2023)