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Literature summary for 3.4.21.104 extracted from

  • Iwaki, D.; Kanno, K.; Takahashi, M.; Endo, Y.; Lynch, N.J.; Schwaeble, W.J.; Matsushita, M.; Okabe, M.; Fujita, T.
    Small mannose-binding lectin-associated protein plays a regulatory role in the lectin complement pathway (2006), J. Immunol., 177, 8626-8632.
    View publication on PubMed
Search for more literature for 3.4.21.104

Activating Compound

Activating Compound Comment Organism Structure
ficolins are pattern recognition proteins acting in innate immunity, and triggering the activation of the lectin complement pathway through MBL-associated serine proteases Mus musculus
mannose-binding lectin MBL, is a pattern recognition protein acting in innate immunity, and triggering the activation of the lectin complement pathway through MBL-associated serine proteases Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information when recombinant sMAP and recombinant MASP-2 reconstitute the MBL-MASP-sMAP complex in deficient serum, the binding of these recombinant proteins to MBL is competitive, and the C4 cleavage activity of the MBL-MASP-sMAP complex is restored by the addition of rMASP-2, whereas the addition of rsMAP attenuates the activity Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
 Mus musculus
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ activates Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
complement component C2 + H2O Mus musculus
-
 ?
-
 ?
complement component C4 + H2O Mus musculus
-
 ?
-
 ?
additional information Mus musculus the enzyme binds to the mannan-binding lectin, the complex activates the lectin pathway of the complement system, overview, a truncated form of MASP-2, named small MBL-associated protein, sMAP, is also associated with MBL/ficolin-MASP complexes, MASP-2 is essential for the activation of C4 and sMAP plays a regulatory role in the activation of the lectin pathway, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Renatured (Commentary)

Renatured (Comment) Organism
reconstitution of the MBL-MASP-sMAP complex using recombinant proteins, overview Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
serum
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
complement component C2 + H2O
-
 Mus musculus ?
-
 ?
complement component C4 + H2O
-
 Mus musculus ?
-
 ?
additional information the enzyme binds to the mannan-binding lectin, the complex activates the lectin pathway of the complement system, overview, a truncated form of MASP-2, named small MBL-associated protein, sMAP, is also associated with MBL/ficolin-MASP complexes, MASP-2 is essential for the activation of C4 and sMAP plays a regulatory role in the activation of the lectin pathway, overview Mus musculus ?
-
 ?
additional information MASP-2 acts in complex with mannan-binding lectin, MBL, a truncated form of MASP-2, named small MBL-associated protein, sMAP, is also associated with MBL/ficolin-MASP complexes, overview Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
MASP-2
-
 Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Mus musculus