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Literature summary for 3.4.21.104 extracted from

  • Moller-Kristensen, M.; Thiel, S.; Sjoeholm, A.; Matsushita, M.; Jensenius, J.C.
    Cooperation between MASP-1 and MASP-2 in the generation of C3 convertase through the MBL pathway (2007), Int. Immunol., 19, 141-149.
    View publication on PubMed
Search for more literature for 3.4.21.104

Activating Compound

Activating Compound Comment Organism Structure
mannan-binding lectin
-
 Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expressed in HEK293 cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information serum depleted of MASP-1, MASP-2 and MASP-3, shows synergetic effect of reconstitution with MASP-1 and MASP-2, overview Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
complement component C4 + H2O Homo sapiens activation to C4b ?
-
 ?
additional information Homo sapiens the lectin pathway is one of the ways leading to the cleavage of complement factor C3, a central event in the activation of the complement system, mannan-binding lectin, MBL, promotes the activation of C3 through the combined action of MASP-1 and MASP-2 without appreciable involvement of the alternative pathway, protease MASP-1 collaborates with MASP-2 in the generation of C3 convertase, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
MBL-derivatized Sepharose column chromatography Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
plasma
-
 Homo sapiens
-
serum
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
complement component C2 + H2O
-
 Homo sapiens complement component C2b + ?
-
 ?
complement component C3 + H2O
-
 Homo sapiens complement component C3b + ?
-
 ?
complement component C4 + H2O activation to C4b Homo sapiens ?
-
 ?
additional information the lectin pathway is one of the ways leading to the cleavage of complement factor C3, a central event in the activation of the complement system, mannan-binding lectin, MBL, promotes the activation of C3 through the combined action of MASP-1 and MASP-2 without appreciable involvement of the alternative pathway, protease MASP-1 collaborates with MASP-2 in the generation of C3 convertase, overview Homo sapiens ?
-
 ?
additional information MASP-2 acts in complex with mannan-binding lectin, MBL, overview Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
MASP-2
-
 Homo sapiens
MASP-2 MASP-2 collaborates with MASP-1 in the generation of C3 convertase Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Homo sapiens