Literature summary for 3.4.19.9 extracted from

Sadahiro, S.; Suzuki, T.; Maeda, Y.; Tanaka, A.; Ogoshi, K.; Kamijo, A.; Murayama, C.; Tsukioka, S.; Sakamoto, E.; Fukui, Y.; Oka, T.
Molecular determinants of folate levels after leucovorin administration in colorectal cancer (2010), Cancer Chemother. Pharmacol., 65, 735-742.

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Application

Application	Comment	Organism
medicine	the relationships between the reduced folate levels in the colorectal cancer tissue after leucovorin administration and the gene-expression levels of folate-metabolizing enzymes and folate transporters is investigated. A multivariate logistic regression analysis reveals that low gamma-glutamyl hydrolase gene expression is a predictive factor for a high reduced folate level after leucovorin administration	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q92820	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
colorectal cancer cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
GGH	-	Homo sapiens
low gamma-glutamyl hydrolase	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	reduced expression of GGH is a predictive factor of a reduced folate level after leucovorin administration in colorectal cancer	down

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Release 2023.1 (January 2023)