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Literature summary for 3.4.19.9 extracted from

  • Jaegerstad, M.; Olsson, I.
    Pteroylpolyglutamate hydrolase of human granulocytes. I. Partial purification and kinetic studies (1979), Scand. J. Clin. Lab. Invest., 39, 343-349.
    View publication on PubMed
Search for more literature for 3.4.19.9

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
6
-
 pteroyltetraglutamate
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm lysosome-like Homo sapiens 5737
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ activation Homo sapiens
Mg2+ activation Homo sapiens
Mn2+ activation Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
pteroylpolyglutamate + H2O Homo sapiens the enzyme is suggested to be involved in the destruction of microorganisms in granulocytes during phagocytosis ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 patients with chronic myeloid leukemia
-

Purification (Commentary)

Purification (Comment) Organism
partial Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
granulocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
pteroylpolyglutamate + H2O the enzyme is suggested to be involved in the destruction of microorganisms in granulocytes during phagocytosis Homo sapiens ?
-
 ?
pteroyltetraglutamate + H2O
-
 Homo sapiens ?
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5.1
-
 pteroyltetraglutamate Homo sapiens