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Literature summary for 3.4.19.9 extracted from

  • Samuels, L.L.; Goutas, L.J.; Priest, D.G.; Piper, J.R.; Sirotnak, F.M.
    Hydrolytic cleavage of methotrexate gamma-polyglutamates by folylpolyglutamyl hydrolase derived from various tumors and normal tissues of the mouse (1986), Cancer Res., 46, 2230-2235.
    View publication on PubMed
Search for more literature for 3.4.19.9

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information Km of methotrexate polyglutamates Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
bone marrow
-
 Mus musculus
-
CCRF S-180 II cell
-
 Mus musculus
-
kidney
-
 Mus musculus
-
L-1210 cell
-
 Mus musculus
-
liver
-
 Mus musculus
-
small intestine
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
methotrexate polyglutamate + H2O
-
 Mus musculus ?
-
 ?
polyglutamylfolate + H2O enzyme from mouse kidney shows mixed endo- and exopeptidase activity, the enzyme from all other normal tissues and tumor cells is consistent with endopeptidase activity Mus musculus ?
-
 ?