Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Mus musculus | - |
lung | - |
Mus musculus | - |
spleen | - |
Mus musculus | - |
uterus | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
leukotriene C4 + H2O | - |
Mus musculus | leukotriene D4 + L-glutamate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
gamma-glutamyl leukotrienase | - |
Mus musculus |
GGL | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | disruption of gamma-glutamyl leukotrienase (GGL) results in disruption of leukotriene D4 synthesis in vivo and attenuation of the acute inflammatory response. In spleen and uterus, deletion of GGL alone abolishes more than 90% of leukotriene D4 synthesis activity. Mice deficient in both gamma-glutamyl transpeptidase (GGT) and GGL have a phenotype similar to the GGT-deficient mice, but about 70% of these mice die before 4 weeks of age, at least 2 months earlier than mice deficient only in GGT. GGL-deficient mice show an attenuation in neutrophil recruitment but not of plasma protein influx | Mus musculus |